SCOP 1.71: Family a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI)

Lineage for Family a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI)

1. Root: SCOP 1.71

2. Class a: All alpha proteins [46456] (226 folds)

3. Fold a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
   multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

4. Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (10 families)
   N-terminal domain is Rossmann-fold with a family-specific C-terminal extension

5. Family a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) [48184] (2 proteins)

Proteins:

1. Class I ketol-acid reductoisomerase [89101] (1 species)

   • Species Pseudomonas aeruginosa [TaxId:287] [89102] (1 PDB entry)

2. Class II ketol-acid reductoisomerase [48185] (1 species)
   duplication; contains two structural repeats swapped to fold into a figure eight knot

   • Species Spinach (Spinacia oleracea) [TaxId:3562] [48186] (2 PDB entries)

More info for Family a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI)

Timeline for Family a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI):

• Family a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) first appeared (with stable ids) in SCOP 1.55, called Family a.100.1.2: Acetohydroxy acid isomeroreductase, ketoacid reductoisomerase (KARI)
  
• Family a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) appears in SCOP 1.69
  
• Family a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) appears in SCOP 1.73
  
• Family a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) appears in the current release, SCOPe 2.08