Lineage for Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2006475Fold a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
    multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
  4. 2006476Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (13 families) (S)
    N-terminal domain is Rossmann-fold with a family-specific C-terminal extension
  5. 2006477Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain [48180] (3 proteins)
    Hydroxyisobutyrate dehydrogenase domain is similar to one structural repeat in the 6-phosphogluconate dehydrogenase domain

Proteins:

  1. 20064786-phosphogluconate dehydrogenase (6PGD) [48181] (2 species)
    duplication; contains two structural repeats
    1. 2006479Species Sheep (Ovis orientalis aries) [TaxId:9940] [48182] (5 PDB entries)
    2. 2006485Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [48183] (1 PDB entry)
  2. 2006488Hydroxyisobutyrate dehydrogenase [101357] (4 species)
    forms similar dimeric and tetrameric structures to the 6-phosphogluconate dehydrogenase domain and its dimer, respectively
    1. 2006489Species Pseudomonas aeruginosa [TaxId:208964] [311277] (1 PDB entry)
    2. 2006491Species Pseudomonas aeruginosa [TaxId:287] [158733] (2 PDB entries)
      Uniprot Q9I5I6 163-296
    3. 2006494Species Salmonella typhimurium [TaxId:90371] [109948] (2 PDB entries)
      Uniprot Q8ZLV8
    4. 2006497Species Thermus thermophilus [TaxId:274] [101358] (2 PDB entries)
      structural genomics
  3. 2006506automated matches [227013] (1 species)
    not a true protein

More info for Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain

Timeline for Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain: