Lineage for Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain

  1. Root: SCOP 1.73
  2. 631650Class a: All alpha proteins [46456] (258 folds)
  3. 645590Fold a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
    multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
  4. 645591Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (12 families) (S)
    N-terminal domain is Rossmann-fold with a family-specific C-terminal extension
  5. 645592Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain [48180] (2 proteins)
    Hydroxyisobutyrate dehydrogenase domain is similar to one structural repeat in the 6-phosphogluconate dehydrogenase domain

Proteins:

  1. 6455936-phosphogluconate dehydrogenase (6PGD) [48181] (2 species)
    duplication; contains two structural repeats
    1. 645594Species Sheep (Ovis orientalis aries) [TaxId:9940] [48182] (5 PDB entries)
    2. 645600Species Trypanosoma brucei [TaxId:5691] [48183] (1 PDB entry)
  2. 645603Hydroxyisobutyrate dehydrogenase [101357] (2 species)
    forms similar dimeric and tetrameric structures to the 6-phosphogluconate dehydrogenase domain and its dimer, respectively
    1. 645604Species Salmonella typhimurium [TaxId:90371] [109948] (1 PDB entry)
    2. 645606Species Thermus thermophilus [TaxId:274] [101358] (2 PDB entries)
      structural genomics

More info for Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain

Timeline for Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain: