Lineage for Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like

  1. Root: SCOPe 2.02
  2. 1074916Class a: All alpha proteins [46456] (284 folds)
  3. 1093870Fold a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
    multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
  4. 1093871Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (12 families) (S)
    N-terminal domain is Rossmann-fold with a family-specific C-terminal extension

Families:

  1. 1093872a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain [48180] (2 proteins)
    Hydroxyisobutyrate dehydrogenase domain is similar to one structural repeat in the 6-phosphogluconate dehydrogenase domain
  2. 1093897a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) [48184] (2 proteins)
  3. 1093914a.100.1.3: HCDH C-domain-like [48187] (2 proteins)
  4. 1093961a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain [48191] (2 proteins)
  5. 1093980a.100.1.5: N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [48194] (1 protein)
  6. 1093984a.100.1.6: Glycerol-3-phosphate dehydrogenase [48197] (1 protein)
  7. 1093998a.100.1.7: Ketopantoate reductase PanE [69084] (1 protein)
  8. 1094006a.100.1.8: Conserved hypothetical protein MTH1747 [74762] (1 protein)
  9. 1094011a.100.1.9: Mannitol 2-dehydrogenase [81843] (1 protein)
  10. 1094017a.100.1.10: ProC C-terminal domain-like [116984] (2 proteins)
    similar dimer to the class I KARI
  11. 1094037a.100.1.11: HMD dimerization domain-like [140777] (1 protein)
    dimer similar to those of the GDP-mannose 6-dehydrogenase and class I KARI domains
  12. 1094041a.100.1.12: TyrA dimerization domain-like [140780] (1 protein)
    new dimerisation mode with swapping of C-terminal helices

More info for Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like

Timeline for Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like: