SCOPe 2.06: Family a.91.1.1: Regulator of G-protein signaling, RGS

Lineage for Family a.91.1.1: Regulator of G-protein signaling, RGS

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.91: Regulator of G-protein signaling, RGS [48096] (1 superfamily)
   multihelical; consists of two all-alpha subdomains
   contains a 4-helical bundle with left-handed twist and up-and-down topology

4. Superfamily a.91.1: Regulator of G-protein signaling, RGS [48097] (2 families)

5. Family a.91.1.1: Regulator of G-protein signaling, RGS [48098] (10 proteins)

Proteins:

1. Axin RGS-homologous domain [48105] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [48106] (2 PDB entries)

2. G-protein coupled receptor kinase 2, N-terminal domain [89090] (1 species)

   • Species Cow (Bos taurus) [TaxId:9913] [89091] (6 PDB entries)

3. Galpha interacting protein, GaIP [48103] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [48104] (1 PDB entry)

4. p115RhoGEF [63584] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [63585] (1 PDB entry)

5. Pdz-RhoGEF RGS-like domain [63586] (1 species)
   contains extra helices in the C-terminal extension

   • Species Human (Homo sapiens) [TaxId:9606] [63587] (1 PDB entry)

6. Regulator of G-protein signaling 16, RGS16 [158689] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [158690] (1 PDB entry)
      Uniprot O15492 65-184

   2. Species Mouse (Mus musculus) [TaxId:10090] [188430] (2 PDB entries)

7. Regulator of G-protein signaling 18, RGS18 [140750] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [140751] (1 PDB entry)
     Uniprot Q9NS28 75-206

8. Regulator of G-protein signaling 4, RGS4 [48099] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [48100] (3 PDB entries)

9. RGS9, RGS domain [48101] (1 species)

   • Species Cow (Bos taurus) [TaxId:9913] [48102] (3 PDB entries)

10. automated matches [190756] (2 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [187954] (3 PDB entries)

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [188643] (3 PDB entries)

More info for Family a.91.1.1: Regulator of G-protein signaling, RGS

Timeline for Family a.91.1.1: Regulator of G-protein signaling, RGS:

• Family a.91.1.1: Regulator of G-protein signaling, RGS first appeared (with stable ids) in SCOP 1.55, called Family a.91.1.1: Regulator of G-protein signalling, RGS
  
• Family a.91.1.1: Regulator of G-protein signaling, RGS appears in SCOPe 2.05
  
• Family a.91.1.1: Regulator of G-protein signaling, RGS appears in SCOPe 2.07
  
• Family a.91.1.1: Regulator of G-protein signaling, RGS appears in the current release, SCOPe 2.08