SCOPe 2.01: Family a.87.1.1: DBL homology domain (DH-domain)

Lineage for Family a.87.1.1: DBL homology domain (DH-domain)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.87: DBL homology domain (DH-domain) [48064] (1 superfamily)
   multihelical; core: 5-helical bundle

4. Superfamily a.87.1: DBL homology domain (DH-domain) [48065] (1 family)

5. Family a.87.1.1: DBL homology domain (DH-domain) [48066] (10 proteins)
   Pfam PF00621

Proteins:

1. beta-pix [48069] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [48070] (1 PDB entry)

2. Dbl's big sister, Dbs [74743] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [74744] (4 PDB entries)
     Uniprot Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence

3. GEF of intersectin [74745] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [74746] (1 PDB entry)

4. GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [48073] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [48074] (1 PDB entry)

5. Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [116957] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [116958] (1 PDB entry)
     Uniprot O15085 714-1081

6. Rho guanine nucleotide exchange factor 12 [109937] (1 species)

   • Species Human (Homo sapiens), gamma isoform [TaxId:9606] [109938] (2 PDB entries)
     Uniprot Q9NZN5 766-1138

7. Rho guanine nucleotide exchange factor 9, Collybistin [158679] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [158680] (1 PDB entry)
     Uniprot Q9QX73 97-299

8. RhoGEF Vav [48071] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [48072] (1 PDB entry)

9. Son of sevenless-1 (sos-1) [48067] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [48068] (3 PDB entries)
     Uniprot Q07889 189-1046

10. Triple functional domain protein TRIO [109935] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [109936] (2 PDB entries)
      Uniprot O75962 1231-1535

More info for Family a.87.1.1: DBL homology domain (DH-domain)

Timeline for Family a.87.1.1: DBL homology domain (DH-domain):

• Family a.87.1.1: DBL homology domain (DH-domain) first appeared (with stable ids) in SCOP 1.55, called Family a.87.1.1: DBL homology domain
  
• Family a.87.1.1: DBL homology domain (DH-domain) appears in SCOP 1.75
  
• Family a.87.1.1: DBL homology domain (DH-domain) appears in SCOPe 2.02
  
• Family a.87.1.1: DBL homology domain (DH-domain) appears in the current release, SCOPe 2.08