SCOPe 2.06: Family a.74.1.1: Cyclin

Lineage for Family a.74.1.1: Cyclin

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.74: Cyclin-like [47953] (1 superfamily)
   core: 5 helices; one helix is surrounded by the others

4. Superfamily a.74.1: Cyclin-like [47954] (4 families)
   duplication: consists of two domains of this fold

5. Family a.74.1.1: Cyclin [47955] (9 proteins)

Proteins:

1. CDK5 activator 1 (NCK5a, p25) [74739] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [74740] (5 PDB entries)
     Uniprot Q15078 145-294

2. Cyclin A [47956] (2 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [47958] (9 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [47957] (81 PDB entries)
      Uniprot P20248 175-432

3. Cyclin H (mcs2) [47959] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47960] (2 PDB entries)

4. Cyclin K [158591] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [158592] (1 PDB entry)
     Uniprot O75909 14-157! Uniprot O75909 158-267

5. Cyclin T1 [158595] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [158596] (10 PDB entries)
     Uniprot O60563 151-259! Uniprot O60563 151-263! Uniprot O60563 5-150! Uniprot O60563 8-150

6. Cyclin-T2 [158593] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [158594] (1 PDB entry)
     Uniprot O60583 150-262! Uniprot O60583 7-149

7. G1/S-specific cyclin-E1 [158597] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [158598] (1 PDB entry)
     Uniprot P24864 103-242! Uniprot P24864 243-372

8. Viral cyclin [47961] (3 species)

   1. Species Herpesvirus saimiri [TaxId:10381] [47962] (7 PDB entries)

   2. Species Kaposi's sarcoma-associated herpesvirus [TaxId:37296] [47964] (1 PDB entry)

   3. Species Murine herpesvirus 68 [TaxId:33708] [47963] (1 PDB entry)

9. automated matches [227027] (3 species)
   not a true protein

   1. Species Cow (Bos taurus) [TaxId:9913] [226306] (3 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [225840] (10 PDB entries)

   3. Species Mouse (Mus musculus) [TaxId:10090] [226547] (2 PDB entries)

More info for Family a.74.1.1: Cyclin

Timeline for Family a.74.1.1: Cyclin:

• Family a.74.1.1: Cyclin first appeared (with stable ids) in SCOP 1.55
  
• Family a.74.1.1: Cyclin appears in SCOPe 2.05
  
• Family a.74.1.1: Cyclin appears in SCOPe 2.07
  
• Family a.74.1.1: Cyclin appears in the current release, SCOPe 2.08