Lineage for Family a.64.1.2: Swaposin

1. Root: SCOP 1.65

2. Class a: All alpha proteins [46456] (179 folds)

3. Fold a.64: Saposin-like [47861] (2 superfamilies) 5 helices; folded leaf, closed

4. Superfamily a.64.1: Saposin [47862] (3 families) Lipid-binding can promote conformational changes and oligomerisation in some members

5. Family a.64.1.2: Swaposin [47866] (1 protein) circularly permuted saposin domain inserted in plant acid proteases