SCOPe 2.08: Superfamily a.60.2: RuvA domain 2-like

Lineage for Superfamily a.60.2: RuvA domain 2-like

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.60: SAM domain-like [47768] (17 superfamilies)
   4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins

4. Superfamily a.60.2: RuvA domain 2-like [47781] (7 families)
   duplication: contains two helix-hairpin-helix (HhH) motifs

Families:

1. a.60.2.1: DNA helicase RuvA subunit, middle domain [47782] (1 protein)

2. a.60.2.2: NAD+-dependent DNA ligase, domain 3 [47786] (1 protein)

3. a.60.2.3: Excinuclease UvrC C-terminal domain [81795] (1 protein)

4. a.60.2.4: Topoisomerase V repeat domain [140626] (1 protein)
   this is a repeat family; one repeat unit is 2csb A:351-409 found in domain

5. a.60.2.5: Hef domain-like [140629] (4 proteins)
   helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain ((81795), that contains a single NMR structure of a monomeric truncated domain, 1kft)

6. a.60.2.6: Tex HhH-containing domain-like [158531] (1 protein)
   tandem repeat of two Ruva_2-like domains

7. a.60.2.7: ComEA-like [158534] (2 proteins)
   sequence similarity to the HhH-motif domains of the PsbU-like and Tex-like families

More info for Superfamily a.60.2: RuvA domain 2-like

Timeline for Superfamily a.60.2: RuvA domain 2-like:

• Superfamily a.60.2: RuvA domain 2-like first appeared (with stable ids) in SCOP 1.55
  
• Superfamily a.60.2: RuvA domain 2-like appears in SCOPe 2.07