Lineage for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain

  1. Root: SCOPe 2.05
  2. 1715731Class a: All alpha proteins [46456] (286 folds)
  3. 1735625Fold a.45: GST C-terminal domain-like [47615] (1 superfamily)
    core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
  4. 1735626Superfamily a.45.1: GST C-terminal domain-like [47616] (3 families) (S)
    this domains follows the thioredoxin-like N-terminal domain
  5. 1735627Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain [47617] (19 protein domains)

Protein Domains:

  1. 1735628Chloride intracellular channel 1 (clic1) [69033] (1 species)
    similar to class theta enzymes; the N-domain undergoes a redox-controlled structural transition
  2. 1735638Class alpha GST [81349] (8 species)
    1. 1735639Species Blood fluke (Schistosoma haematobium) [TaxId:6185] [89060] (4 PDB entries)
    2. 1735647Species Fasciola hepatica [TaxId:6192] [47634] (2 PDB entries)
    3. 1735651Species Human (Homo sapiens), (a1-1) [TaxId:9606] [47625] (27 PDB entries)
      Uniprot P08263
    4. 1735744Species Mouse (Mus musculus), (a1-1) [TaxId:10090] [47627] (2 PDB entries)
    5. 1735749Species Mouse (Mus musculus), (a1-4) [TaxId:10090] [47628] (2 PDB entries)
    6. 1735754Species Mouse (Mus musculus), (a2-2) [TaxId:10090] [89059] (1 PDB entry)
    7. 1735757Species Norway rat (Rattus norvegicus), (a1-1) [TaxId:10116] [47626] (2 PDB entries)
    8. 1735764Species Schistosoma japonicum [TaxId:6182] [47633] (13 PDB entries)
      Uniprot P08515
  3. 1735780Class beta GST [81357] (4 species)
    1. 1735781Species Escherichia coli [TaxId:562] [47638] (3 PDB entries)
    2. 1735787Species Ochrobactrum anthropi [TaxId:529] [225312] (2 PDB entries)
    3. 1735790Species Proteus mirabilis [TaxId:584] [47639] (2 PDB entries)
    4. 1735796Species Sphingomonas paucimobilis [TaxId:13689] [47640] (1 PDB entry)
  4. 1735801Class delta GST [81355] (6 species)
    formerly a part of class theta enzymes
    1. 1735802Species African malaria mosquito (Anopheles gambiae), isozyme 1-6 [TaxId:7165] [101209] (1 PDB entry)
    2. 1735805Species Anopheles dirus [TaxId:7168] [224848] (2 PDB entries)
    3. 1735810Species Mosquito (Anopheles dirus b), isozyme 1-3 [TaxId:123217] [74724] (1 PDB entry)
    4. 1735817Species Mosquito (Anopheles dirus b), isozyme 1-4 [TaxId:123217] [74725] (1 PDB entry)
    5. 1735820Species Mosquito (Anopheles dirus b), isozyme 1-5 [TaxId:123217] [101207] (1 PDB entry)
    6. 1735822Species Mosquito (Anopheles dirus b), isozyme 1-6 [TaxId:123217] [101208] (1 PDB entry)
  5. 1735827Class mu GST [81348] (3 species)
    1. 1735828Species Chicken (Gallus gallus) [TaxId:9031] [47624] (2 PDB entries)
    2. 1735835Species Human (Homo sapiens) [TaxId:9606] [47622] (15 PDB entries)
      Uniprot P09488 P28161
    3. 1735889Species Norway rat (Rattus norvegicus) [TaxId:10116] [47623] (16 PDB entries)
  6. 1735925Class omega GST [81352] (1 species)
  7. 1735928Class phi GST [81356] (3 species)
    1. 1735929Species Maize (Zea mays), type I [TaxId:4577] [47636] (2 PDB entries)
    2. 1735936Species Maize (Zea mays), type III [TaxId:4577] [47637] (1 PDB entry)
    3. 1735938Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [47635] (2 PDB entries)
  8. 1735942Class pi GST [81347] (4 species)
    1. 1735943Species Human (Homo sapiens) [TaxId:9606] [47619] (52 PDB entries)
    2. 1736063Species Mouse (Mus musculus) [TaxId:10090] [47621] (10 PDB entries)
    3. 1736088Species Onchocerca volvulus [TaxId:6282] [116911] (2 PDB entries)
      Uniprot P46427
    4. 1736095Species Pig (Sus scrofa) [TaxId:9823] [47620] (1 PDB entry)
  9. 1736098Class sigma GST [81351] (5 species)
    1. 1736099Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [81771] (1 PDB entry)
    2. 1736102Species Heligmosomoides polygyrus [TaxId:6339] [109834] (1 PDB entry)
      Uniprot Q9NJQ6 # Fragment
    3. 1736111Species Human (Homo sapiens) [TaxId:9606] [89061] (7 PDB entries)
      Uniprot O60760; synonym: hematopoietic prostaglandin D synthase
    4. 1736138Species Norway rat (Rattus norvegicus) [TaxId:10116] [47630] (1 PDB entry)
      synonym: hematopoietic prostaglandin D synthase
    5. 1736141Species Squid (Ommastrephes sloani pacificus) [TaxId:6634] [47631] (2 PDB entries)
  10. 1736144Class tau GST [81354] (2 species)
    1. 1736145Species Aegilops tauschii, also known as Triticum tauschii [TaxId:37682] [74726] (1 PDB entry)
    2. 1736149Species Rice (Oryza sativa) [TaxId:4530] [89062] (1 PDB entry)
  11. 1736154Class theta GST [81350] (1 species)
  12. 1736162Class zeta GST [81353] (2 species)
    1. 1736163Species Human (Homo sapiens) [TaxId:9606] [63555] (1 PDB entry)
      maleylacetoacetate isomerase
    2. 1736165Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [63556] (1 PDB entry)
  13. 1736167Glutaredoxin 2 [63557] (1 species)
    similar to class zeta enzymes
  14. 1736170GST-like domain of elongation factor 1-gamma [81772] (1 species)
  15. 1736173Hypothetical protein AGR_pAT_752p/Atu5508 [140558] (1 species)
    putative glutathione S-transferase
  16. 1736177Microsomal prostaglandin E synthase-2 [140556] (1 species)
  17. 1736187Pf GST [101210] (1 species)
    cannot be assigned to any of the known GST classes
  18. 1736201Yeast prion protein ure2p, nitrogen regulation fragment [47641] (1 species)
    similar to class phi enzymes
  19. 1736229automated matches [226848] (11 species)
    not a true protein
    1. 1736230Species Blood fluke (Schistosoma haematobium) [TaxId:6185] [225081] (4 PDB entries)
    2. 1736238Species Blood fluke (Schistosoma mansoni) [TaxId:6183] [224992] (1 PDB entry)
    3. 1736240Species Brugia malayi [TaxId:6279] [279266] (1 PDB entry)
    4. 1736243Species Escherichia coli [TaxId:83333] [256898] (2 PDB entries)
    5. 1736246Species Human (Homo sapiens) [TaxId:9606] [224956] (38 PDB entries)
    6. 1736365Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [225818] (3 PDB entries)
    7. 1736372Species Mouse (Mus musculus) [TaxId:10090] [225047] (2 PDB entries)
    8. 1736376Species Salmonella enterica [TaxId:99287] [225743] (1 PDB entry)
    9. 1736378Species Schistosoma japonicum [TaxId:6182] [225615] (2 PDB entries)
    10. 1736382Species Shigella flexneri [TaxId:198215] [226693] (1 PDB entry)
    11. 1736387Species Wuchereria bancrofti [TaxId:6293] [226430] (1 PDB entry)

More info for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain

Timeline for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain: