Lineage for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain

  1. Root: SCOPe 2.01
  2. 901761Class a: All alpha proteins [46456] (284 folds)
  3. 915607Fold a.45: GST C-terminal domain-like [47615] (1 superfamily)
    core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
  4. 915608Superfamily a.45.1: GST C-terminal domain-like [47616] (2 families) (S)
    this domains follows the thioredoxin-like N-terminal domain
  5. 915609Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain [47617] (18 proteins)

Proteins:

  1. 915610Chloride intracellular channel 1 (clic1) [69033] (1 species)
    similar to class theta enzymes; the N-domain undergoes a redox-controlled structural transition
  2. 915620Class alpha GST [81349] (8 species)
    1. 915621Species Blood fluke (Schistosoma haematobium) [TaxId:6185] [89060] (8 PDB entries)
    2. 915636Species Fasciola hepatica [TaxId:6192] [47634] (2 PDB entries)
    3. 915640Species Human (Homo sapiens), (a1-1) [TaxId:9606] [47625] (19 PDB entries)
      Uniprot P08263
    4. 915697Species Mouse (Mus musculus), (a1-1) [TaxId:10090] [47627] (2 PDB entries)
    5. 915702Species Mouse (Mus musculus), (a1-4) [TaxId:10090] [47628] (2 PDB entries)
    6. 915707Species Mouse (Mus musculus), (a2-2) [TaxId:10090] [89059] (1 PDB entry)
    7. 915710Species Rat (Rattus norvegicus), (a1-1) [TaxId:10116] [47626] (2 PDB entries)
    8. 915717Species Schistosoma japonicum [TaxId:6182] [47633] (12 PDB entries)
      Uniprot P08515
  3. 915733Class beta GST [81357] (3 species)
    1. 915734Species Escherichia coli [TaxId:562] [47638] (3 PDB entries)
    2. 915740Species Proteus mirabilis [TaxId:584] [47639] (2 PDB entries)
    3. 915746Species Sphingomonas paucimobilis [TaxId:13689] [47640] (1 PDB entry)
  4. 915751Class delta GST [81355] (5 species)
    formerly a part of class theta enzymes
    1. 915752Species African malaria mosquito (Anopheles gambiae), isozyme 1-6 [TaxId:7165] [101209] (1 PDB entry)
    2. 915755Species Mosquito (Anopheles dirus b), isozyme 1-3 [TaxId:123217] [74724] (1 PDB entry)
    3. 915762Species Mosquito (Anopheles dirus b), isozyme 1-4 [TaxId:123217] [74725] (1 PDB entry)
    4. 915765Species Mosquito (Anopheles dirus b), isozyme 1-5 [TaxId:123217] [101207] (1 PDB entry)
    5. 915767Species Mosquito (Anopheles dirus b), isozyme 1-6 [TaxId:123217] [101208] (1 PDB entry)
  5. 915772Class mu GST [81348] (3 species)
    1. 915773Species Chicken (Gallus gallus) [TaxId:9031] [47624] (2 PDB entries)
    2. 915780Species Human (Homo sapiens) [TaxId:9606] [47622] (15 PDB entries)
      Uniprot P09488 P28161
    3. 915834Species Norway rat (Rattus norvegicus) [TaxId:10116] [47623] (16 PDB entries)
  6. 915870Class omega GST [81352] (1 species)
  7. 915873Class phi GST [81356] (3 species)
    1. 915874Species Maize (Zea mays), type I [TaxId:4577] [47636] (2 PDB entries)
    2. 915881Species Maize (Zea mays), type III [TaxId:4577] [47637] (1 PDB entry)
    3. 915883Species Mouse-ear cress (Arabidopsis thaliana) [TaxId:3702] [47635] (2 PDB entries)
  8. 915887Class pi GST [81347] (4 species)
    1. 915888Species Human (Homo sapiens) [TaxId:9606] [47619] (41 PDB entries)
    2. 915984Species Mouse (Mus musculus) [TaxId:10090] [47621] (9 PDB entries)
    3. 916007Species Onchocerca volvulus [TaxId:6282] [116911] (2 PDB entries)
      Uniprot P46427
    4. 916014Species Pig (Sus scrofa) [TaxId:9823] [47620] (1 PDB entry)
  9. 916017Class sigma GST [81351] (5 species)
    1. 916018Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [81771] (1 PDB entry)
    2. 916021Species Heligmosomoides polygyrus [TaxId:6339] [109834] (1 PDB entry)
      Uniprot Q9NJQ6 # Fragment
    3. 916030Species Human (Homo sapiens) [TaxId:9606] [89061] (11 PDB entries)
      Uniprot O60760; synonym: hematopoietic prostaglandin D synthase
    4. 916073Species Norway rat (Rattus norvegicus) [TaxId:10116] [47630] (1 PDB entry)
      synonym: hematopoietic prostaglandin D synthase
    5. 916076Species Squid (Ommastrephes sloani pacificus) [TaxId:6634] [47631] (2 PDB entries)
  10. 916079Class tau GST [81354] (2 species)
    1. 916080Species Aegilops tauschii, also known as Triticum tauschii [TaxId:37682] [74726] (1 PDB entry)
    2. 916084Species Rice (Oryza sativa) [TaxId:4530] [89062] (1 PDB entry)
  11. 916089Class theta GST [81350] (1 species)
  12. 916097Class zeta GST [81353] (2 species)
    1. 916098Species Human (Homo sapiens) [TaxId:9606] [63555] (1 PDB entry)
      maleylacetoacetate isomerase
    2. 916100Species Mouse-ear cress (Arabidopsis thaliana) [TaxId:3702] [63556] (1 PDB entry)
  13. 916102Glutaredoxin 2 [63557] (1 species)
    similar to class zeta enzymes
  14. 916105GST-like domain of elongation factor 1-gamma [81772] (1 species)
  15. 916108Hypothetical protein AGR_pAT_752p/Atu5508 [140558] (1 species)
    putative glutathione S-transferase
  16. 916112Microsomal prostaglandin E synthase-2 [140556] (1 species)
  17. 916122Pf GST [101210] (1 species)
    cannot be assigned to any of the known GST classes
  18. 916132Yeast prion protein ure2p, nitrogen regulation fragment [47641] (1 species)
    similar to class phi enzymes

More info for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain

Timeline for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain: