SCOP 1.75: Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain

Lineage for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.45: GST C-terminal domain-like [47615] (1 superfamily)
   core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix

4. Superfamily a.45.1: GST C-terminal domain-like [47616] (2 families)
   this domains follows the thioredoxin-like N-terminal domain

5. Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain [47617] (18 proteins)

Proteins:

1. Chloride intracellular channel 1 (clic1) [69033] (1 species)
   similar to class theta enzymes; the N-domain undergoes a redox-controlled structural transition

   • Species Human (Homo sapiens) [TaxId:9606] [69034] (4 PDB entries)

2. Class alpha GST [81349] (8 species)

   1. Species Blood fluke (Schistosoma haematobium) [TaxId:6185] [89060] (8 PDB entries)

   2. Species Fasciola hepatica [TaxId:6192] [47634] (2 PDB entries)

   3. Species Human (Homo sapiens), (a1-1) [TaxId:9606] [47625] (19 PDB entries)
      Uniprot P08263

   4. Species Mouse (Mus musculus), (a1-1) [TaxId:10090] [47627] (2 PDB entries)

   5. Species Mouse (Mus musculus), (a1-4) [TaxId:10090] [47628] (2 PDB entries)

   6. Species Mouse (Mus musculus), (a2-2) [TaxId:10090] [89059] (1 PDB entry)

   7. Species Rat (Rattus norvegicus), (a1-1) [TaxId:10116] [47626] (2 PDB entries)

   8. Species Schistosoma japonicum [TaxId:6182] [47633] (12 PDB entries)
      Uniprot P08515

3. Class beta GST [81357] (3 species)

   1. Species Escherichia coli [TaxId:562] [47638] (3 PDB entries)

   2. Species Proteus mirabilis [TaxId:584] [47639] (2 PDB entries)

   3. Species Sphingomonas paucimobilis [TaxId:13689] [47640] (1 PDB entry)

4. Class delta GST [81355] (5 species)
   formerly a part of class theta enzymes

   1. Species African malaria mosquito (Anopheles gambiae), isozyme 1-6 [TaxId:7165] [101209] (1 PDB entry)

   2. Species Mosquito (Anopheles dirus b), isozyme 1-3 [TaxId:123217] [74724] (1 PDB entry)

   3. Species Mosquito (Anopheles dirus b), isozyme 1-4 [TaxId:123217] [74725] (1 PDB entry)

   4. Species Mosquito (Anopheles dirus b), isozyme 1-5 [TaxId:123217] [101207] (1 PDB entry)

   5. Species Mosquito (Anopheles dirus b), isozyme 1-6 [TaxId:123217] [101208] (1 PDB entry)

5. Class mu GST [81348] (3 species)

   1. Species Chicken (Gallus gallus) [TaxId:9031] [47624] (2 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [47622] (15 PDB entries)
      Uniprot P09488 P28161

   3. Species Rat (Rattus norvegicus) [TaxId:10116] [47623] (16 PDB entries)

6. Class omega GST [81352] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47632] (1 PDB entry)

7. Class phi GST [81356] (3 species)

   1. Species Maize (Zea mays), type I [TaxId:4577] [47636] (2 PDB entries)

   2. Species Maize (Zea mays), type III [TaxId:4577] [47637] (1 PDB entry)

   3. Species Mouse-ear cress (Arabidopsis thaliana) [TaxId:3702] [47635] (2 PDB entries)

8. Class pi GST [81347] (4 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [47619] (41 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [47621] (9 PDB entries)

   3. Species Onchocerca volvulus [TaxId:6282] [116911] (2 PDB entries)
      Uniprot P46427

   4. Species Pig (Sus scrofa) [TaxId:9823] [47620] (1 PDB entry)

9. Class sigma GST [81351] (5 species)

   1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [81771] (1 PDB entry)

   2. Species Heligmosomoides polygyrus [TaxId:6339] [109834] (1 PDB entry)
      Uniprot Q9NJQ6 # Fragment

   3. Species Human (Homo sapiens) [TaxId:9606] [89061] (11 PDB entries)
      Uniprot O60760; synonym: hematopoietic prostaglandin D synthase

   4. Species Rat (Rattus norvegicus) [TaxId:10116] [47630] (1 PDB entry)
      synonym: hematopoietic prostaglandin D synthase

   5. Species Squid (Ommastrephes sloani pacificus) [TaxId:6634] [47631] (2 PDB entries)

10. Class tau GST [81354] (2 species)

    1. Species Aegilops tauschii, also known as Triticum tauschii [TaxId:37682] [74726] (1 PDB entry)

    2. Species Rice (Oryza sativa) [TaxId:4530] [89062] (1 PDB entry)

11. Class theta GST [81350] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [47629] (3 PDB entries)

12. Class zeta GST [81353] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [63555] (1 PDB entry)
       maleylacetoacetate isomerase

    2. Species Mouse-ear cress (Arabidopsis thaliana) [TaxId:3702] [63556] (1 PDB entry)

13. Glutaredoxin 2 [63557] (1 species)
    similar to class zeta enzymes

    • Species Escherichia coli [TaxId:562] [63558] (1 PDB entry)

14. GST-like domain of elongation factor 1-gamma [81772] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [81773] (1 PDB entry)

15. Hypothetical protein AGR_pAT_752p/Atu5508 [140558] (1 species)
    putative glutathione S-transferase

    • Species Agrobacterium tumefaciens [TaxId:358] [140559] (1 PDB entry)
      Uniprot Q7D2W7 88-236

16. Microsomal prostaglandin E synthase-2 [140556] (1 species)

    • Species Crab-eating macaque (Macaca fascicularis) [TaxId:9541] [140557] (2 PDB entries)
      Uniprot Q9N0A4 213-373

17. Pf GST [101210] (1 species)
    cannot be assigned to any of the known GST classes

    • Species Malarial parasite (Plasmodium falciparum) [TaxId:5833] [101211] (4 PDB entries)

18. Yeast prion protein ure2p, nitrogen regulation fragment [47641] (1 species)
    similar to class phi enzymes

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [47642] (8 PDB entries)

More info for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain

Timeline for Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain:

• Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain first appeared (with stable ids) in SCOP 1.55, called Family a.45.1.1: Glutathione S-transferases, C-terminal domain
  
• Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain appears in SCOP 1.73
  
• Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain appears in SCOPe 2.01
  
• Family a.45.1.1: Glutathione S-transferase (GST), C-terminal domain appears in the current release, SCOPe 2.08