SCOPe 2.06: Family a.42.1.1: SWIB/MDM2 domain

Lineage for Family a.42.1.1: SWIB/MDM2 domain

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
   core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
   duplication: consists of two structural repeats

4. Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families)
   binds to the transactivation domain of human p53

5. Family a.42.1.1: SWIB/MDM2 domain [47593] (5 proteins)
   Pfam PF02201

Proteins:

1. Hypothetical protein AT5G08430 (rafl09-47-k03) [101201] (1 species)

   • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [101202] (1 PDB entry)

2. Hypothetical protein AT5G14170 (rafl11-05-p19) [101199] (1 species)

   • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [101200] (1 PDB entry)

3. MDM2 [47594] (2 species)

   1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [47595] (12 PDB entries)
      Uniprot P56273 13-119

   2. Species Human (Homo sapiens) [TaxId:9606] [47596] (59 PDB entries)

4. SWI/SNF related regulator of chromatin (BRG1-associated factor 60a) [109832] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [109833] (1 PDB entry)
     Uniprot Q61466 252-331

5. automated matches [254465] (1 species)
   not a true protein

   • Species Human (Homo sapiens) [TaxId:9606] [254996] (3 PDB entries)

More info for Family a.42.1.1: SWIB/MDM2 domain

Timeline for Family a.42.1.1: SWIB/MDM2 domain:

• Family a.42.1.1: SWIB/MDM2 domain first appeared (with stable ids) in SCOP 1.55, called Family a.42.1.1: MDM2
  
• Family a.42.1.1: SWIB/MDM2 domain appears in SCOPe 2.05
  
• Family a.42.1.1: SWIB/MDM2 domain appears in SCOPe 2.07
  
• Family a.42.1.1: SWIB/MDM2 domain appears in the current release, SCOPe 2.08