Lineage for Family a.39.1.7: EF-hand modules in multidomain proteins

  1. Root: SCOP 1.73
  2. 631650Class a: All alpha proteins [46456] (258 folds)
  3. 640657Fold a.39: EF Hand-like [47472] (4 superfamilies)
    core: 4 helices; array of 2 hairpins, opened
  4. 640658Superfamily a.39.1: EF-hand [47473] (11 families) (S)
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
  5. 641256Family a.39.1.7: EF-hand modules in multidomain proteins [47547] (7 proteins)

Proteins:

  1. 641257alpha-Actinin [63553] (1 species)
  2. 641260Cbl [47561] (1 species)
  3. 641268Diacylglycerol kinase alpha, N-terminal domain [116905] (1 species)
    contains two pairs of EF-hands, the modified first pair (res 25-109) does not bind calcium but retains the common fold
  4. 641271DJ-1-binding protein, DJBP [140536] (1 species)
  5. 641277Dystrophin [47559] (1 species)
    probably lost calcium-binding function; contains extra helices in each domain
  6. 641283Nucleobindin 1 (CALNUC) [109825] (1 species)
  7. 641286Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!) [47548] (1 species)

More info for Family a.39.1.7: EF-hand modules in multidomain proteins

Timeline for Family a.39.1.7: EF-hand modules in multidomain proteins: