Lineage for Family a.39.1.7: EF-hand modules in multidomain proteins

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2319424Fold a.39: EF Hand-like [47472] (4 superfamilies)
    core: 4 helices; array of 2 hairpins, opened
  4. 2319425Superfamily a.39.1: EF-hand [47473] (12 families) (S)
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
  5. 2320611Family a.39.1.7: EF-hand modules in multidomain proteins [47547] (9 proteins)

Proteins:

  1. 2320612alpha-Actinin [63553] (1 species)
  2. 2320615Cbl [47561] (1 species)
  3. 2320635Diacylglycerol kinase alpha, N-terminal domain [116905] (1 species)
    contains two pairs of EF-hands, the modified first pair (res 25-109) does not bind calcium but retains the common fold
  4. 2320638DJ-1-binding protein, DJBP [140536] (1 species)
  5. 2320641Dystrophin [47559] (1 species)
    probably lost calcium-binding function; contains extra helices in each domain
  6. 2320647Nucleobindin 1 (CALNUC) [109825] (1 species)
  7. 2320650Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!) [47548] (1 species)
  8. 2320673Phospholipase C-beta-2 [158478] (1 species)
  9. 2320677automated matches [190808] (1 species)
    not a true protein

More info for Family a.39.1.7: EF-hand modules in multidomain proteins

Timeline for Family a.39.1.7: EF-hand modules in multidomain proteins: