Lineage for Protein: Calmodulin

  1. Root: SCOP 1.73
  2. 631650Class a: All alpha proteins [46456] (258 folds)
  3. 640657Fold a.39: EF Hand-like [47472] (4 superfamilies)
    core: 4 helices; array of 2 hairpins, opened
  4. 640658Superfamily a.39.1: EF-hand [47473] (11 families) (S)
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
  5. 640871Family a.39.1.5: Calmodulin-like [47502] (23 proteins)
    Duplication: made with two pairs of EF-hands
  6. 640930Protein Calmodulin [47516] (10 species)

Species:

  1. 640931African frog (Xenopus laevis) [TaxId:8355] [47521] (11 PDB entries)
    1. Domain for 1cfc:
    2. Domain for 1cfd:
    3. Domain for 1cff:
      • 640941Domain d1cffa_: 1cff A: [17295]
        complex with a binding peptide of the human Ca2+-pump
        complexed with ca
    4. Domain for 1ckk:
      • 640942Domain d1ckka_: 1ckk A: [17294]
        complex with a fragment of the rat ca2+/calmodulin dependent protein kinase
        complexed with ca
    5. Domain for 1dmo:
    6. Domain for 1f70:
    7. Domain for 1f71:
    8. Domain for 1iq5:
      • 640932Domain d1iq5a_: 1iq5 A: [62643]
        complex with a ca2+/calmodulin dependent kinase kinase fragment
        complexed with ca
    9. Domain for 1mux:
    10. Domain for 1nwd:
      • 640943Domain d1nwda_: 1nwd A: [86297]
        complex with the C-terminal fragment of glutamate decarboxylase, chains B and C
        complexed with ca
    11. Domains for 2ggm:
      1. 640933Domain d2ggma1: 2ggm A:24-166 [135152]
        automatically matched to d1cfc__
        complexed with ca
      2. 640934Domain d2ggmb1: 2ggm B:25-166 [135153]
        automatically matched to d1cfc__
        complexed with ca
  2. 640944Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89052] (3 PDB entries)
    1. Domain for 1f54:
    2. Domain for 1f55:
      • 640947Domain d1f55a_: 1f55 A: [83245]
        N-terminal domain, calcium bound form
        complexed with ca
    3. Domain for 1lkj:
  3. 640948Chicken (Gallus gallus) [TaxId:9031] [47520] (1 PDB entry)
    mutant with a two residue deletion in the central helix
  4. 640950Ciliate (Paramecium tetraurelia) [TaxId:5888] [47523] (4 PDB entries)
    1. Domain for 1clm:
    2. Domain for 1exr:
    3. Domains for 1n0y:
      1. 640953Domain d1n0ya_: 1n0y A: [91536]
      2. 640954Domain d1n0yb_: 1n0y B: [91537]
        complexed with act, cac, pb
    4. Domain for 1osa:
  5. 640956Cow (Bos taurus) [TaxId:9913] [47518] (25 PDB entries)
    1. Domain for 1a29:
      • 640973Domain d1a29a_: 1a29 A: [17276]
        trifluoperazine 1:2 complex
        complexed with ca, tfp
    2. Domain for 1ak8:
    3. Domains for 1cdl:
      1. 640965Domain d1cdla_: 1cdl A: [17272]
      2. 640966Domain d1cdlb_: 1cdl B: [17273]
      3. 640967Domain d1cdlc_: 1cdl C: [17274]
      4. 640968Domain d1cdld_: 1cdl D: [17275]
        complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase
        complexed with ca
    4. Domain for 1cdm:
      • 640962Domain d1cdma_: 1cdm A: [17270]
        complexed with calmodulin-binding domain of calmodulin-dependent protein kinase
        complexed with ca
    5. Domain for 1cm1:
    6. Domains for 1cm4:
      1. 640969Domain d1cm4a_: 1cm4 A: [17266]
      2. 640970Domain d1cm4c_: 1cm4 C: [17267]
      3. 640971Domain d1cm4e_: 1cm4 E: [17268]
      4. 640972Domain d1cm4g_: 1cm4 G: [17269]
        complexed with ca
    7. Domain for 1cmf:
    8. Domain for 1cmg:
    9. Domain for 1deg:
    10. Domain for 1fw4:
    11. Domain for 1j7o:
    12. Domain for 1j7p:
    13. Domain for 1lin:
    14. Domain for 1prw:
    15. Domain for 1qiv:
    16. Domains for 1qiw:
      1. 640974Domain d1qiwa_: 1qiw A: [17277]
      2. 640975Domain d1qiwb_: 1qiw B: [17278]
        complexed with ca, dpd
    17. Domains for 1up5:
      1. 640959Domain d1up5a1: 1up5 A:4-75 [119696]
        automatically matched to d1ak8__
        complexed with ca, m3l
      2. 640960Domain d1up5b1: 1up5 B:4-75 [119697]
        automatically matched to d1ak8__
        complexed with ca, m3l
    18. Domain for 1xa5:
    19. Domains for 1xfu:
      1. 641003Domain d1xfuo1: 1xfu O:3-75 [121937]
        automatically matched to d1ak8__
        complexed with ca, mg; mutant
      2. 641004Domain d1xfup1: 1xfu P:3-75 [121938]
        automatically matched to d1ak8__
        complexed with ca, mg; mutant
      3. 641005Domain d1xfuq1: 1xfu Q:3-75 [121939]
        automatically matched to d1ak8__
        complexed with ca, mg; mutant
      4. 641006Domain d1xfur1: 1xfu R:3-75 [121940]
        automatically matched to d1ak8__
        complexed with ca, mg; mutant
      5. 641007Domain d1xfus1: 1xfu S:3-75 [121941]
        automatically matched to d1ak8__
        complexed with ca, mg; mutant
      6. 641008Domain d1xfut1: 1xfu T:3-75 [121942]
        automatically matched to d1ak8__
        complexed with ca, mg; mutant
    20. Domains for 1xfv:
      1. 641009Domain d1xfvo1: 1xfv O:3-75 [121943]
        automatically matched to d1ak8__
        complexed with 3at, ca, mg
      2. 641010Domain d1xfvp1: 1xfv P:3-75 [121944]
        automatically matched to d1ak8__
        complexed with 3at, ca, mg
      3. 641011Domain d1xfvq1: 1xfv Q:3-75 [121945]
        automatically matched to d1ak8__
        complexed with 3at, ca, mg
      4. 641012Domain d1xfvr1: 1xfv R:3-75 [121946]
        automatically matched to d1ak8__
        complexed with 3at, ca, mg
      5. 641013Domain d1xfvs1: 1xfv S:3-75 [121947]
        automatically matched to d1ak8__
        complexed with 3at, ca, mg
      6. 641014Domain d1xfvt1: 1xfv T:3-75 [121948]
        automatically matched to d1ak8__
        complexed with 3at, ca, mg
    21. Domains for 1xfw:
      1. 640991Domain d1xfwo1: 1xfw O:3-75 [121949]
        automatically matched to d1ak8__
        complexed with ca, cmp, mg
      2. 640992Domain d1xfwp1: 1xfw P:3-75 [121950]
        automatically matched to d1ak8__
        complexed with ca, cmp, mg
      3. 640993Domain d1xfwq1: 1xfw Q:3-75 [121951]
        automatically matched to d1ak8__
        complexed with ca, cmp, mg
      4. 640994Domain d1xfwr1: 1xfw R:3-75 [121952]
        automatically matched to d1ak8__
        complexed with ca, cmp, mg
      5. 640995Domain d1xfws1: 1xfw S:3-75 [121953]
        automatically matched to d1ak8__
        complexed with ca, cmp, mg
      6. 640996Domain d1xfwt1: 1xfw T:3-75 [121954]
        automatically matched to d1ak8__
        complexed with ca, cmp, mg
    22. Domains for 1xfx:
      1. 640977Domain d1xfxo1: 1xfx O:3-75 [121955]
        automatically matched to d1ak8__
        complexed with ca, mg
      2. 640978Domain d1xfxp1: 1xfx P:3-75 [121956]
        automatically matched to d1ak8__
        complexed with ca, mg
      3. 640979Domain d1xfxq1: 1xfx Q:3-75 [121957]
        automatically matched to d1ak8__
        complexed with ca, mg
      4. 640980Domain d1xfxr1: 1xfx R:3-75 [121958]
        automatically matched to d1ak8__
        complexed with ca, mg
      5. 640981Domain d1xfxs1: 1xfx S:3-75 [121959]
        automatically matched to d1ak8__
        complexed with ca, mg
      6. 640982Domain d1xfxt1: 1xfx T:3-75 [121960]
        automatically matched to d1ak8__
        complexed with ca, mg
    23. Domains for 1xfy:
      1. 640997Domain d1xfyo1: 1xfy O:3-75 [121961]
        automatically matched to d1ak8__
        complexed with ca, mg
      2. 640998Domain d1xfyp1: 1xfy P:3-75 [121962]
        automatically matched to d1ak8__
        complexed with ca, mg
      3. 640999Domain d1xfyq1: 1xfy Q:3-75 [121963]
        automatically matched to d1ak8__
        complexed with ca, mg
      4. 641000Domain d1xfyr1: 1xfy R:3-75 [121964]
        automatically matched to d1ak8__
        complexed with ca, mg
      5. 641001Domain d1xfys1: 1xfy S:3-75 [121965]
        automatically matched to d1ak8__
        complexed with ca, mg
      6. 641002Domain d1xfyt1: 1xfy T:3-75 [121966]
        automatically matched to d1ak8__
        complexed with ca, mg
    24. Domains for 1xfz:
      1. 640983Domain d1xfzo1: 1xfz O:3-75 [121967]
        automatically matched to d1ak8__
        complexed with ca, mg
      2. 640984Domain d1xfzp1: 1xfz P:3-75 [121968]
        automatically matched to d1ak8__
        complexed with ca, mg
      3. 640985Domain d1xfzq1: 1xfz Q:3-75 [121969]
        automatically matched to d1ak8__
        complexed with ca, mg
      4. 640986Domain d1xfzr1: 1xfz R:3-75 [121970]
        automatically matched to d1ak8__
        complexed with ca, mg
      5. 640987Domain d1xfzs1: 1xfz S:3-75 [121971]
        automatically matched to d1ak8__
        complexed with ca, mg
      6. 640988Domain d1xfzt1: 1xfz T:3-75 [121972]
        automatically matched to d1ak8__
        complexed with ca, mg
    25. Domain for 2fce:
  6. 641020Drosophila melanogaster [TaxId:7227] [47522] (4 PDB entries)
    1. Domains for 1mxe:
      1. 641021Domain d1mxea_: 1mxe A: [79644]
      2. 641022Domain d1mxeb_: 1mxe B: [79645]
        complex with the target sequence of Calmodulin-dependent protein kinase I (1a06), chains E and F
        complexed with ca
    2. Domain for 2bbm:
    3. Domain for 2bbn:
    4. Domain for 4cln:
  7. 641026Human (Homo sapiens) [TaxId:9606] [47517] (11 PDB entries)
    1. Domain for 1cll:
    2. Domain for 1ctr:
      • 641030Domain d1ctra_: 1ctr A: [17264]
        trifluoperazine 1:1 complex
        complexed with ca, tfp
    3. Domain for 1iwq:
      • 641028Domain d1iwqa_: 1iwq A: [83761]
        complexed with Marcks calmodulin binding domain peptide, chain B
        complexed with ca
    4. Domains for 1k90:
      1. 641031Domain d1k90d_: 1k90 D: [68322]
        Other proteins in same PDB: d1k90a_, d1k90b_, d1k90c_
      2. 641032Domain d1k90e_: 1k90 E: [68323]
        Other proteins in same PDB: d1k90a_, d1k90b_, d1k90c_
      3. 641033Domain d1k90f_: 1k90 F: [68324]
        Other proteins in same PDB: d1k90a_, d1k90b_, d1k90c_
        complexed with 3at, ca, yb
    5. Domains for 1k93:
      1. 641037Domain d1k93d_: 1k93 D: [68330]
        Other proteins in same PDB: d1k93a_, d1k93b_, d1k93c_
      2. 641038Domain d1k93e_: 1k93 E: [68331]
        Other proteins in same PDB: d1k93a_, d1k93b_, d1k93c_
      3. 641039Domain d1k93f_: 1k93 F: [68332]
        Other proteins in same PDB: d1k93a_, d1k93b_, d1k93c_
        complexed with ca, so4
    6. Domain for 1l7z:
      • 641029Domain d1l7za_: 1l7z A: [91054]
        complexed with a myristoylated peptide, chain B
        complexed with ca, myr
    7. Domains for 1lvc:
      1. 641046Domain d1lvcd_: 1lvc D: [78239]
        Other proteins in same PDB: d1lvca_, d1lvcb_, d1lvcc_
      2. 641047Domain d1lvce_: 1lvc E: [78240]
        Other proteins in same PDB: d1lvca_, d1lvcb_, d1lvcc_
      3. 641048Domain d1lvcf_: 1lvc F: [78241]
        Other proteins in same PDB: d1lvca_, d1lvcb_, d1lvcc_
        complexed with ca, dot, yb
    8. Domains for 1pk0:
      1. 641040Domain d1pk0d_: 1pk0 D: [94798]
        Other proteins in same PDB: d1pk0a_, d1pk0b_, d1pk0c_
      2. 641041Domain d1pk0e_: 1pk0 E: [94799]
        Other proteins in same PDB: d1pk0a_, d1pk0b_, d1pk0c_
      3. 641042Domain d1pk0f_: 1pk0 F: [94800]
        Other proteins in same PDB: d1pk0a_, d1pk0b_, d1pk0c_
        complexed with ca, ema, yb
    9. Domains for 1s26:
      1. 641034Domain d1s26d_: 1s26 D: [98370]
        Other proteins in same PDB: d1s26a_, d1s26b_, d1s26c_
      2. 641035Domain d1s26e_: 1s26 E: [98371]
        Other proteins in same PDB: d1s26a_, d1s26b_, d1s26c_
      3. 641036Domain d1s26f_: 1s26 F: [98372]
        Other proteins in same PDB: d1s26a_, d1s26b_, d1s26c_
        complexed with apc, ca, yb
    10. Domains for 1sk6:
      1. 641043Domain d1sk6d_: 1sk6 D: [105668]
        Other proteins in same PDB: d1sk6a_, d1sk6b_, d1sk6c_
      2. 641044Domain d1sk6e_: 1sk6 E: [105669]
        Other proteins in same PDB: d1sk6a_, d1sk6b_, d1sk6c_
      3. 641045Domain d1sk6f_: 1sk6 F: [105670]
        Other proteins in same PDB: d1sk6a_, d1sk6b_, d1sk6c_
        complexed with ca, cmp, pop, yb
    11. Domain for 1sw8:
      • 641049Domain d1sw8a_: 1sw8 A: [99022]
        N-terminal domain only
        complexed with ca; mutant
  8. 641050Nematode (Caenorhabditis elegans) [TaxId:6239] [89051] (1 PDB entry)
  9. 641052Potato (Solanum tuberosum) [TaxId:4113] [109820] (1 PDB entry)
  10. 641054Rat (Rattus rattus) [TaxId:10117] [47519] (5 PDB entries)
    1. Domain for 1g4y:
    2. Domains for 1niw:
      1. 641056Domain d1niwa_: 1niw A: [80537]
      2. 641057Domain d1niwc_: 1niw C: [80538]
      3. 641058Domain d1niwe_: 1niw E: [80539]
      4. 641059Domain d1niwg_: 1niw G: [80540]
        complexed with an endothelial nitric oxide synthase peptide, chains B, D, F and H
        complexed with ca, egl, mse, so4
    3. Domains for 1qx5:
      1. 641061Domain d1qx5b_: 1qx5 B: [104628]
      2. 641062Domain d1qx5d_: 1qx5 D: [104629]
      3. 641063Domain d1qx5i_: 1qx5 I: [104630]
      4. 641064Domain d1qx5j_: 1qx5 J: [104631]
      5. 641065Domain d1qx5k_: 1qx5 K: [104632]
      6. 641066Domain d1qx5r_: 1qx5 R: [104633]
      7. 641067Domain d1qx5t_: 1qx5 T: [104634]
      8. 641068Domain d1qx5y_: 1qx5 Y: [104635]
        apocalmodulin; oligomer with swapped EF-hand units
    4. Domains for 1qx7:
      1. 641069Domain d1qx7a_: 1qx7 A: [104636]
      2. 641070Domain d1qx7b_: 1qx7 B: [104637]
      3. 641071Domain d1qx7i_: 1qx7 I: [104638]
      4. 641072Domain d1qx7m_: 1qx7 M: [104639]
      5. 641073Domain d1qx7r_: 1qx7 R: [104640]
        apocalmodulin; oligomer with swapped EF-hand units
    5. Domain for 3cln:

More info for Protein Calmodulin from a.39.1.5: Calmodulin-like

Timeline for Protein Calmodulin from a.39.1.5: Calmodulin-like: