SCOP 1.75: Family a.39.1.5: Calmodulin-like

Lineage for Family a.39.1.5: Calmodulin-like

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.39: EF Hand-like [47472] (4 superfamilies)
   core: 4 helices; array of 2 hairpins, opened

4. Superfamily a.39.1: EF-hand [47473] (11 families)
   Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop

5. Family a.39.1.5: Calmodulin-like [47502] (23 proteins)
   Duplication: made with two pairs of EF-hands

Proteins:

1. Calcineurin B-like protein 2 [101182] (1 species)

   • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [101183] (2 PDB entries)

2. Calcineurin regulatory subunit (B-chain) [47530] (2 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [47531] (2 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [47532] (3 PDB entries)

3. Calcium vector protein [47514] (1 species)

   • Species Amphioxus (Branchiostoma lanceolatum) [TaxId:7740] [47515] (4 PDB entries)

4. Calcium- and integrin-binding protein, CIB [47541] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47542] (4 PDB entries)
     Uniprot Q99828

5. Calcium-dependent protein kinase sk5 CLD [109821] (1 species)

   • Species Soybean (Glycine max) [TaxId:3847] [109822] (2 PDB entries)
     Uniprot P28583 328-508

6. Calcium-regulated photoprotein [47512] (4 species)
   structurally most similar to sarcoplasmic calcium-binding protein

   1. Species Hydrozoa (Obelia geniculata), obelin [TaxId:185004] [63542] (1 PDB entry)

   2. Species Hydrozoa (Obelia longissima), obelin [TaxId:32570] [63541] (7 PDB entries)
      Uniprot Q27709

   3. Species Jellyfish (Aequorea aequorea), aequorin [TaxId:168712] [47513] (5 PDB entries)

   4. Species Jellyfish (Aequorea victoria), aequorin 1 [TaxId:6100] [116901] (1 PDB entry)
      Uniprot P07164 16-196

7. Calerythrin [101179] (1 species)
   structurally most similar to sarcoplasmic calcium-binding protein

   • Species Saccharopolyspora erythraea [TaxId:1836] [101180] (1 PDB entry)

8. Calmodulin [47516] (11 species)

   1. Species African frog (Xenopus laevis) [TaxId:8355] [47521] (12 PDB entries)

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89052] (3 PDB entries)

   3. Species Chicken (Gallus gallus) [TaxId:9031] [47520] (2 PDB entries)
      mutant with a two residue deletion in the central helix

   4. Species Ciliate (Paramecium tetraurelia) [TaxId:5888] [47523] (4 PDB entries)
      Uniprot Q42478

   5. Species Cow (Bos taurus) [TaxId:9913] [47518] (25 PDB entries)
      Uniprot P62157

   6. Species Drosophila melanogaster [TaxId:7227] [47522] (6 PDB entries)

   7. Species Human (Homo sapiens) [TaxId:9606] [47517] (38 PDB entries)
      Uniprot P02593

   8. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89051] (1 PDB entry)

   9. Species Potato (Solanum tuberosum) [TaxId:4113] [109820] (1 PDB entry)

   10. Species Rat (Rattus rattus) [TaxId:10117] [47519] (5 PDB entries)
       Uniprot P62161

   11. Species Rattus norvegicus [TaxId:10116] [158477] (2 PDB entries)

9. Calmodulin-related protein NB-1 (CLP) [74721] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [74722] (1 PDB entry)

10. Calmodulin-related protein T21P5.17 [109823] (1 species)

    • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [109824] (1 PDB entry)
      Uniprot Q9SRP5 2-67

11. Caltractin (centrin 2) [89053] (2 species)

    1. Species Green algae (Chlamydomonas reinhardtii) [TaxId:3055] [89055] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [89054] (5 PDB entries)

12. Cdc4p [63543] (1 species)

    • Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [63544] (1 PDB entry)

13. EHCABP [69021] (1 species)

    • Species Entamoeba (Entamoeba histolytica) [TaxId:5759] [69022] (2 PDB entries)

14. Frequenin (neuronal calcium sensor 1) [47535] (2 species)

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [47536] (2 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [63545] (1 PDB entry)

15. Guanylate cyclase activating protein 2, GCAP-2 [47537] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [47538] (1 PDB entry)

16. Kchip1, Kv4 potassium channel-interacting protein [101184] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [116902] (1 PDB entry)
       Uniprot Q9NZI2

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [101185] (1 PDB entry)

17. Myosin Essential Chain [47524] (3 species)

    1. Species Bay scallop (Aequipecten irradians) [TaxId:31199] [47525] (13 PDB entries)
       Uniprot P13543

    2. Species Chicken (Gallus gallus) [TaxId:9031] [47526] (4 PDB entries)

    3. Species Human (Homo sapiens) [TaxId:9606] [101181] (3 PDB entries)

18. Myosin Light Chain Mlc1p [81756] (1 species)
    light chain of class V myosin

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [81757] (3 PDB entries)

19. Myosin Regulatory Chain [47527] (2 species)

    1. Species Bay scallop (Aequipecten irradians) [TaxId:31199] [47528] (13 PDB entries)
       Uniprot P07291

    2. Species Chicken (Gallus gallus) [TaxId:9031] [47529] (1 PDB entry)

20. Neurocalcin [47539] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [47540] (1 PDB entry)

21. Recoverin [47533] (1 species)
    Calcium-myristoyl switch; only one EF-hand is functional

    • Species Cow (Bos taurus) [TaxId:9913] [47534] (8 PDB entries)

22. Sarcoplasmic calcium-binding protein [47509] (2 species)

    1. Species Amphioxus (Branchiostoma lanceolatum) [TaxId:7740] [47511] (1 PDB entry)

    2. Species Sandworm (Nereis diversicolor) [TaxId:126592] [47510] (2 PDB entries)
       Uniprot P04571

23. Troponin C [47503] (6 species)

    1. Species Chicken (Gallus gallus) [TaxId:9031] [47504] (28 PDB entries)
       Uniprot P09860

    2. Species Chicken (Gallus gallus), cardiac isoform [TaxId:9031] [47507] (1 PDB entry)

    3. Species Human (Homo sapiens), cardiac isoform [TaxId:9606] [47508] (15 PDB entries)

    4. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [47506] (4 PDB entries)

    5. Species Rainbow trout (Oncorhynchus mykiss) [TaxId:8022] [109819] (2 PDB entries)
       Uniprot Q7ZZB9 1-89

    6. Species Turkey (Meleagris gallopavo) [TaxId:9103] [47505] (2 PDB entries)

More info for Family a.39.1.5: Calmodulin-like

Timeline for Family a.39.1.5: Calmodulin-like:

• Family a.39.1.5: Calmodulin-like first appeared (with stable ids) in SCOP 1.55
  
• Family a.39.1.5: Calmodulin-like appears in SCOP 1.73
  
• Family a.39.1.5: Calmodulin-like appears in SCOPe 2.01
  
• Family a.39.1.5: Calmodulin-like appears in the current release, SCOPe 2.08