SCOP 1.63: Family a.39.1.5: Calmodulin-like

Lineage for Family a.39.1.5: Calmodulin-like

1. Root: SCOP 1.63

2. Class a: All alpha proteins [46456] (171 folds)

3. Fold a.39: EF Hand-like [47472] (4 superfamilies)
   core: 4 helices; array of 2 hairpins, opened

4. Superfamily a.39.1: EF-hand [47473] (9 families)
   Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop

5. Family a.39.1.5: Calmodulin-like [47502] (17 proteins)
   Duplication: made with two pairs of EF-hands

Proteins:

1. Calcineurin regulatory subunit (B-chain) [47530] (2 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [47531] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [47532] (3 PDB entries)

2. Calcium vector protein [47514] (1 species)

   • Species Amphioxus (Branchiostoma lanceolatum) [TaxId:7740] [47515] (4 PDB entries)

3. Calcium- and integrin-binding protein, CIB [47541] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47542] (2 PDB entries)

4. Calcium-regulated photoprotein [47512] (3 species)
   structurally most similar to sarcoplasmic calcium-binding protein

   1. Species Hydrozoa (Obelia geniculata), obelin [TaxId:185004] [63542] (1 PDB entry)

   2. Species Hydrozoa (Obelia longissima), obelin [TaxId:32570] [63541] (2 PDB entries)

   3. Species Jellyfish (Aequorea aequorea), aequorin [TaxId:168712] [47513] (1 PDB entry)

5. Calmodulin [47516] (7 species)

   1. Species African frog (Xenopus laevis) [TaxId:8355] [47521] (9 PDB entries)

   2. Species Chicken (Gallus gallus) [TaxId:9031] [47520] (1 PDB entry)
      mutant with a two residue deletion in the central helix

   3. Species Ciliate (Paramecium tetraurelia) [TaxId:5888] [47523] (3 PDB entries)

   4. Species Cow (Bos taurus) [TaxId:9913] [47518] (15 PDB entries)

   5. Species Drosophila melanogaster [TaxId:7227] [47522] (4 PDB entries)

   6. Species Human (Homo sapiens) [TaxId:9606] [47517] (5 PDB entries)

   7. Species Rat (Rattus rattus) [TaxId:10117] [47519] (3 PDB entries)

6. Calmodulin-related protein NB-1 (CLP) [74721] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [74722] (1 PDB entry)

7. Cdc4p [63543] (1 species)

   • Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [63544] (1 PDB entry)

8. EHCABP [69021] (1 species)

   • Species Entamoeba (Entamoeba histolytica) [TaxId:5759] [69022] (2 PDB entries)

9. Frequenin (neuronal calcium sensor 1) [47535] (2 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [47536] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [63545] (1 PDB entry)

10. Guanylate cyclase activating protein 2, GCAP-2 [47537] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [47538] (1 PDB entry)

11. Myosin Essential Chain [47524] (2 species)

    1. Species Bay scallop (Aequipecten irradians) [TaxId:31199] [47525] (10 PDB entries)

    2. Species Chicken (Gallus gallus) [TaxId:9031] [47526] (3 PDB entries)

12. Myosin Light Chain Mlc1p [81756] (1 species)
    light chain of class V myosin

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [81757] (2 PDB entries)

13. Myosin Regulatory Chain [47527] (2 species)

    1. Species Bay scallop (Aequipecten irradians) [TaxId:31199] [47528] (10 PDB entries)

    2. Species Chicken (Gallus gallus) [TaxId:9031] [47529] (1 PDB entry)

14. Neurocalcin [47539] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [47540] (1 PDB entry)

15. Recoverin [47533] (1 species)
    Calcium-myristoyl switch; only one EF-hand is functional

    • Species Cow (Bos taurus) [TaxId:9913] [47534] (4 PDB entries)

16. Sarcoplasmic calcium-binding protein [47509] (2 species)

    1. Species Amphioxus (Branchiostoma lanceolatum) [TaxId:7740] [47511] (1 PDB entry)

    2. Species Sandworm (Nereis diversicolor) [TaxId:126592] [47510] (1 PDB entry)

17. Troponin C [47503] (5 species)

    1. Species Chicken (Gallus gallus) [TaxId:9031] [47504] (23 PDB entries)

    2. Species Chicken (Gallus gallus), cardiac isoform [TaxId:9031] [47507] (1 PDB entry)

    3. Species Human (Homo sapiens), cardiac isoform [TaxId:9606] [47508] (5 PDB entries)

    4. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [47506] (4 PDB entries)

    5. Species Turkey (Meleagris gallopavo) [TaxId:9103] [47505] (2 PDB entries)

More info for Family a.39.1.5: Calmodulin-like

Timeline for Family a.39.1.5: Calmodulin-like:

• Family a.39.1.5: Calmodulin-like first appeared (with stable ids) in SCOP 1.55
  
• Family a.39.1.5: Calmodulin-like appears in SCOP 1.61
  
• Family a.39.1.5: Calmodulin-like appears in SCOP 1.65
  
• Family a.39.1.5: Calmodulin-like appears in the current release, SCOPe 2.08