SCOP 1.67: Superfamily a.39.1: EF-hand

Lineage for Superfamily a.39.1: EF-hand

1. Root: SCOP 1.67

2. Class a: All alpha proteins [46456] (202 folds)

3. Fold a.39: EF Hand-like [47472] (4 superfamilies)
   core: 4 helices; array of 2 hairpins, opened

4. Superfamily a.39.1: EF-hand [47473] (10 families)
   Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop

Families:

1. a.39.1.1: Calbindin D9K [47474] (1 protein)
   made of two EF-hands only

2. a.39.1.2: S100 proteins [47478] (1 protein)
   dimer: subunits are made of two EF-hands

3. a.39.1.3: Osteonectin [47489] (1 protein)
   5 helices; two EF-hands plus one of additional helices in the N-terminal part

4. a.39.1.4: Parvalbumin [47492] (2 proteins)
   6-helices; array of 3 hairpins, closed
   made with two-helical hairpin and two EF-hands

5. a.39.1.5: Calmodulin-like [47502] (21 proteins)
   Duplication: made with two pairs of EF-hands

6. a.39.1.6: Eps15 homology domain (EH domain) [47543] (3 proteins)

7. a.39.1.7: EF-hand modules in multidomain proteins [47547] (4 proteins)

8. a.39.1.8: Penta-EF-hand proteins [63550] (5 proteins)

9. a.39.1.9: Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [81758] (1 protein)
   4 EF-hands assembled in a compact structure like the Penta-EF-hand proteins; contains additional N-terminal all-alpha subdomain

10. a.39.1.10: Polcalcin [89048] (2 proteins)
    calcium-binding pollen allergen; two EF-hands per subunit

More info for Superfamily a.39.1: EF-hand

Timeline for Superfamily a.39.1: EF-hand:

• Superfamily a.39.1: EF-hand first appeared (with stable ids) in SCOP 1.55
  
• Superfamily a.39.1: EF-hand appears in SCOP 1.65
  
• Superfamily a.39.1: EF-hand appears in SCOP 1.69
  
• Superfamily a.39.1: EF-hand appears in the current release, SCOPe 2.08