Lineage for Superfamily a.39.1: EF-hand

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1994319Fold a.39: EF Hand-like [47472] (4 superfamilies)
    core: 4 helices; array of 2 hairpins, opened
  4. 1994320Superfamily a.39.1: EF-hand [47473] (12 families) (S)
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop

Families:

  1. 1994321a.39.1.1: Calbindin D9K [47474] (2 protein domains)
    made of two EF-hands only
  2. 1994353a.39.1.2: S100 proteins [47478] (2 protein domains)
    dimer: subunits are made of two EF-hands
  3. 1994678a.39.1.3: Osteonectin [47489] (1 protein)
    5 helices; two EF-hands plus one of additional helices in the N-terminal part
  4. 1994686a.39.1.4: Parvalbumin [47492] (3 protein domains)
    6-helices; array of 3 hairpins, closed
    made with two-helical hairpin and two EF-hands
  5. 1994753a.39.1.5: Calmodulin-like [47502] (24 protein domains)
    Duplication: made with two pairs of EF-hands
  6. 1995426a.39.1.6: Eps15 homology domain (EH domain) [47543] (3 protein domains)
  7. 1995442a.39.1.7: EF-hand modules in multidomain proteins [47547] (9 protein domains)
  8. 1995514a.39.1.8: Penta-EF-hand proteins [63550] (7 protein domains)
  9. 1995603a.39.1.9: Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [81758] (1 protein)
    4 EF-hands assembled in a compact structure like the Penta-EF-hand proteins; contains additional N-terminal all-alpha subdomain
  10. 1995608a.39.1.10: Polcalcin [89048] (3 protein domains)
    calcium-binding pollen allergen; two EF-hands per subunit
  11. 1995626a.39.1.11: p25-alpha [140538] (2 protein domains)
    Pfam PF05517; comprises two degenerate EF-hands and extra C-terminal helix, packed agains the bundle end
  12. 1995633a.39.1.0: automated matches [191396] (1 protein)
    not a true family

More info for Superfamily a.39.1: EF-hand

Timeline for Superfamily a.39.1: EF-hand: