Lineage for Family a.27.1.1: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991849Fold a.27: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1 superfamily)
    core: 4 helices; bundle; one loop crosses over one side of the bundle
  4. 1991850Superfamily a.27.1: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47323] (2 families) (S)
  5. 1991851Family a.27.1.1: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47324] (6 protein domains)

Protein Domains:

  1. 1991852Arginyl-tRNA synthetase (ArgRS) [47333] (2 species)
    1. 1991853Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [47334] (3 PDB entries)
    2. 1991857Species Thermus thermophilus [TaxId:274] [69007] (1 PDB entry)
  2. 1991859Cysteinyl-tRNA synthetase (CysRS) [74709] (1 species)
    contains extra C-terminal alpha+beta subdomain: [alpha(2)-beta(2)], ordered in the complex with tRNA
  3. 1991866Isoleucyl-tRNA synthetase (IleRS) [47328] (2 species)
    1. 1991867Species Staphylococcus aureus [TaxId:1280] [47330] (3 PDB entries)
      contains additional alpha+beta and Zn-binding domains in the C-terminal extension
    2. 1991871Species Thermus thermophilus [TaxId:274] [47329] (3 PDB entries)
  4. 1991875Leucyl-tRNA synthetase (LeuRS) [81746] (1 species)
  5. 1991880Methionyl-tRNA synthetase (MetRS) [47325] (3 species)
    this domain follows the Rossmann-fold catalytic domain of class I aaRS
    1. 1991881Species Escherichia coli [TaxId:562] [47327] (9 PDB entries)
    2. 1991891Species Pyrococcus abyssi [TaxId:29292] [109792] (1 PDB entry)
      Uniprot Q9V011 1-606 # C-domain 616-722 is solved separately: 1MKH
    3. Species Thermus thermophilus [TaxId:274] [47326] (1 PDB entry)
  6. 1991895Valyl-tRNA synthetase (ValRS) [47331] (1 species)
    includes additional alpha+beta (sub)domain at the C-terminus

More info for Family a.27.1.1: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

Timeline for Family a.27.1.1: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases: