Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 1991729Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 protein domains)
    contains an additional helix in one of the crossover connections
  6. 1991767Protein Interferon-gamma [47318] (3 species)
    intertwined dimer
  7. 1991775Species Human (Homo sapiens) [TaxId:9606] [47320] (4 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1eku:
    1. 1991786Domain d1ekua1: 1eku A:0-121 [16911]
      biologically active single chain mutant
      complexed with so4; mutant
    2. 1991787Domain d1ekua2: 1eku A:123-242 [16912]
      biologically active single chain mutant
      complexed with so4; mutant
    3. 1991788Domain d1ekub1: 1eku B:0-121 [16913]
      biologically active single chain mutant
      complexed with so4; mutant
    4. 1991789Domain d1ekub2: 1eku B:123-241 [16914]
      biologically active single chain mutant
      complexed with so4; mutant
  2. Domain(s) for 1fg9:
    1. 1991780Domain d1fg9a_: 1fg9 A: [16915]
      Other proteins in same PDB: d1fg9c1, d1fg9c2, d1fg9d1, d1fg9d2, d1fg9e1, d1fg9e2
    2. 1991781Domain d1fg9b_: 1fg9 B: [16916]
      Other proteins in same PDB: d1fg9c1, d1fg9c2, d1fg9d1, d1fg9d2, d1fg9e1, d1fg9e2
  3. Domain(s) for 1fyh:
    1. 1991776Domain d1fyha1: 1fyh A:0-124 [16907]
      Other proteins in same PDB: d1fyhb1, d1fyhb2, d1fyhe1, d1fyhe2
      a single-chain variant
      complexed with cl
    2. 1991777Domain d1fyha2: 1fyh A:201-324 [16908]
      Other proteins in same PDB: d1fyhb1, d1fyhb2, d1fyhe1, d1fyhe2
      a single-chain variant
      complexed with cl
    3. 1991778Domain d1fyhd1: 1fyh D:0-124 [16909]
      Other proteins in same PDB: d1fyhb1, d1fyhb2, d1fyhe1, d1fyhe2
      a single-chain variant
      complexed with cl
    4. 1991779Domain d1fyhd2: 1fyh D:201-324 [16910]
      Other proteins in same PDB: d1fyhb1, d1fyhb2, d1fyhe1, d1fyhe2
      a single-chain variant
      complexed with cl
  4. Domain(s) for 1hig:
    1. 1991782Domain d1higa_: 1hig A: [16917]
      CA-atoms only
    2. 1991783Domain d1higb_: 1hig B: [16918]
      CA-atoms only
    3. 1991784Domain d1higc_: 1hig C: [16919]
      CA-atoms only
    4. 1991785Domain d1higd_: 1hig D: [16920]
      CA-atoms only

More info for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.3 Interferon-gamma

Timeline for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.3 Interferon-gamma: