Lineage for Protein: Interferon-gamma

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 1991729Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 protein domains)
    contains an additional helix in one of the crossover connections
  6. 1991767Protein Interferon-gamma [47318] (3 species)
    intertwined dimer

Species:

  1. 1991768Cow (Bos taurus) [TaxId:9913] [47319] (3 PDB entries)
    1. Domains for 1d9c:
      1. 1991769Domain d1d9ca_: 1d9c A: [16901]
      2. 1991770Domain d1d9cb_: 1d9c B: [16902]
    2. Domains for 1d9g:
      1. 1991771Domain d1d9ga_: 1d9g A: [16903]
      2. 1991772Domain d1d9gb_: 1d9g B: [16904]
    3. Domains for 1rfb:
      1. 1991773Domain d1rfba_: 1rfb A: [16905]
      2. 1991774Domain d1rfbb_: 1rfb B: [16906]
  2. 1991775Human (Homo sapiens) [TaxId:9606] [47320] (4 PDB entries)
    1. Domains for 1eku:
      1. 1991786Domain d1ekua1: 1eku A:0-121 [16911]
        biologically active single chain mutant
        complexed with so4; mutant
      2. 1991787Domain d1ekua2: 1eku A:123-242 [16912]
        biologically active single chain mutant
        complexed with so4; mutant
      3. 1991788Domain d1ekub1: 1eku B:0-121 [16913]
        biologically active single chain mutant
        complexed with so4; mutant
      4. 1991789Domain d1ekub2: 1eku B:123-241 [16914]
        biologically active single chain mutant
        complexed with so4; mutant
    2. Domains for 1fg9:
      1. 1991780Domain d1fg9a_: 1fg9 A: [16915]
        Other proteins in same PDB: d1fg9c1, d1fg9c2, d1fg9d1, d1fg9d2, d1fg9e1, d1fg9e2
      2. 1991781Domain d1fg9b_: 1fg9 B: [16916]
        Other proteins in same PDB: d1fg9c1, d1fg9c2, d1fg9d1, d1fg9d2, d1fg9e1, d1fg9e2
    3. Domains for 1fyh:
      1. 1991776Domain d1fyha1: 1fyh A:0-124 [16907]
        Other proteins in same PDB: d1fyhb1, d1fyhb2, d1fyhe1, d1fyhe2
        a single-chain variant
        complexed with cl
      2. 1991777Domain d1fyha2: 1fyh A:201-324 [16908]
        Other proteins in same PDB: d1fyhb1, d1fyhb2, d1fyhe1, d1fyhe2
        a single-chain variant
        complexed with cl
      3. 1991778Domain d1fyhd1: 1fyh D:0-124 [16909]
        Other proteins in same PDB: d1fyhb1, d1fyhb2, d1fyhe1, d1fyhe2
        a single-chain variant
        complexed with cl
      4. 1991779Domain d1fyhd2: 1fyh D:201-324 [16910]
        Other proteins in same PDB: d1fyhb1, d1fyhb2, d1fyhe1, d1fyhe2
        a single-chain variant
        complexed with cl
    4. Domains for 1hig:
      1. 1991782Domain d1higa_: 1hig A: [16917]
        CA-atoms only
      2. 1991783Domain d1higb_: 1hig B: [16918]
        CA-atoms only
      3. 1991784Domain d1higc_: 1hig C: [16919]
        CA-atoms only
      4. 1991785Domain d1higd_: 1hig D: [16920]
        CA-atoms only
  3. 1991790Rabbit (Oryctolagus cuniculus) [TaxId:9986] [47321] (1 PDB entry)

More info for Protein Interferon-gamma from a.26.1.3: Interferons/interleukin-10 (IL-10)

Timeline for Protein Interferon-gamma from a.26.1.3: Interferons/interleukin-10 (IL-10):