SCOPe 2.08: Protein: Interleukin-10 (cytokine synthesis inhibitory factor, CSIF)

Lineage for Protein: Interleukin-10 (cytokine synthesis inhibitory factor, CSIF)

Root: SCOPe 2.08
Class a: All alpha proteins [46456] (290 folds)
Fold a.26: 4-helical cytokines [47265] (1 superfamily)
core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
there are two different topoisomers of this fold with different entanglements of the two crossover connections
Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins)
contains an additional helix in one of the crossover connections
Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
intertwined dimer, similar to interferon-gamma

Species:

Epstein-Barr virus [TaxId:10376] [47308] (3 PDB entries)
1. Domain for 1vlk:
  - Domain d1vlka_: 1vlk A: [16888]
2. Domain for 1y6m:
  - Domain d1y6ml_: 1y6m L: [122665]
    Other proteins in same PDB: d1y6mr1, d1y6mr2
    automated match to d1vlk__
3. Domain for 1y6n:
  - Domain d1y6nl1: 1y6n L:12-157 [144600]
    Other proteins in same PDB: d1y6nr1, d1y6nr2
    mutant
Human (Homo sapiens) [TaxId:9606] [47307] (6 PDB entries)
1. Domain for 1ilk:
  - Domain d1ilka_: 1ilk A: [16886]
2. Domain for 1inr:
  - Domain d1inra_: 1inr A: [16887]
3. Domain for 1j7v:
  - Domain d1j7vl_: 1j7v L: [62704]
    Other proteins in same PDB: d1j7vr1, d1j7vr2
    complexed with IL-10 receptor 1 (IL-10R1)
4. Domains for 1lk3:
  1. Domain d1lk3a_: 1lk3 A: [73950]
    Other proteins in same PDB: d1lk3h1, d1lk3h2, d1lk3i1, d1lk3i2, d1lk3l1, d1lk3l2, d1lk3m1, d1lk3m2
  2. Domain d1lk3b_: 1lk3 B: [73951]
    Other proteins in same PDB: d1lk3h1, d1lk3h2, d1lk3i1, d1lk3i2, d1lk3l1, d1lk3l2, d1lk3m1, d1lk3m2
5. Domain for 1y6k:
  - Domain d1y6kl_: 1y6k L: [122662]
    Other proteins in same PDB: d1y6kr1, d1y6kr2
    automated match to d2ilk__
6. Domain for 2ilk:
  - Domain d2ilka_: 2ilk A: [16885]
    complexed with so4
Human herpesvirus 5 [TaxId:10359] [74708] (1 PDB entry)
- Domains for 1lqs:
  1. Domain d1lqsl_: 1lqs L: [74192]
    Other proteins in same PDB: d1lqsr1, d1lqsr2, d1lqss1, d1lqss2
    complexed with nag
  2. Domain d1lqsm_: 1lqs M: [74193]
    Other proteins in same PDB: d1lqsr1, d1lqsr2, d1lqss1, d1lqss2
    complexed with nag

More info for Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) from a.26.1.3: Interferons/interleukin-10 (IL-10)

Timeline for Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) from a.26.1.3: Interferons/interleukin-10 (IL-10):

Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) from a.26.1.3: Interferons/interleukin-10 (IL-10) first appeared (with stable ids) in SCOP 1.55
Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) from a.26.1.3: Interferons/interleukin-10 (IL-10) appears in SCOPe 2.07