Lineage for Family a.26.1.3: Interferons/interleukin-10 (IL-10)

  1. Root: SCOP 1.75
  2. 758332Class a: All alpha proteins [46456] (284 folds)
  3. 767022Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 767023Superfamily a.26.1: 4-helical cytokines [47266] (3 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 767210Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (8 proteins)
    contains an additional helix in one of the crossover connections

Proteins:

  1. 767211Interferon-alpha 2a [47314] (1 species)
  2. 767215Interferon-alpha 2b [47312] (1 species)
  3. 767223Interferon-beta [47309] (2 species)
    1. 767224Species Human (Homo sapiens) [TaxId:9606] [47310] (1 PDB entry)
    2. 767227Species Mouse (Mus musculus) [TaxId:10090] [47311] (2 PDB entries)
      Uniprot P01575 22-182
      CA-atoms only
  4. 767230Interferon-gamma [47318] (3 species)
    intertwined dimer
    1. 767231Species Cow (Bos taurus) [TaxId:9913] [47319] (3 PDB entries)
    2. 767238Species Human (Homo sapiens) [TaxId:9606] [47320] (5 PDB entries)
    3. 767254Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [47321] (1 PDB entry)
  5. 767256Interferon-tau [47316] (1 species)
  6. 767259Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
    intertwined dimer, similar to interferon-gamma
    1. 767260Species Epstein-Barr virus [TaxId:10376] [47308] (3 PDB entries)
    2. 767264Species Human (Homo sapiens) [TaxId:9606] [47307] (7 PDB entries)
    3. 767273Species Human herpesvirus 5 [TaxId:10359] [74708] (1 PDB entry)
  7. 767276Interleukin-19 [81744] (1 species)
  8. 767279Interleukin-22 (IL-22) [89036] (1 species)

More info for Family a.26.1.3: Interferons/interleukin-10 (IL-10)

Timeline for Family a.26.1.3: Interferons/interleukin-10 (IL-10):