Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 1991528Family a.26.1.2: Short-chain cytokines [47286] (14 protein domains)
  6. 1991585Protein Interleukin-2 (IL-2) [47301] (1 species)
  7. 1991586Species Human (Homo sapiens) [TaxId:9606] [47302] (16 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1irl:
  2. Domain(s) for 1m47:
  3. Domain(s) for 1m48:
    1. 1991587Domain d1m48a_: 1m48 A: [74443]
      complexed with frg
    2. 1991588Domain d1m48b_: 1m48 B: [74444]
      complexed with frg
  4. Domain(s) for 1m49:
    1. 1991590Domain d1m49a_: 1m49 A: [74445]
      complexed with cmm
    2. 1991591Domain d1m49b_: 1m49 B: [74446]
      complexed with cmm
  5. Domain(s) for 1m4a:
  6. Domain(s) for 1m4b:
  7. Domain(s) for 1m4c:
    1. 1991598Domain d1m4ca_: 1m4c A: [74449]
    2. 1991599Domain d1m4cb_: 1m4c B: [74450]
  8. Domain(s) for 1nbp:
  9. Domain(s) for 1pw6:
    1. 1991600Domain d1pw6a_: 1pw6 A: [95200]
      complexed with a small molecule inhibitor
      complexed with frb, so4
    2. 1991601Domain d1pw6b_: 1pw6 B: [95201]
      complexed with a small molecule inhibitor
      complexed with frb, so4
  10. Domain(s) for 1py2:
    1. 1991609Domain d1py2a_: 1py2 A: [95319]
      complexed with a small molecule inhibitor
      complexed with frh, zn
    2. 1991610Domain d1py2b_: 1py2 B: [95320]
      complexed with a small molecule inhibitor
      complexed with frh, zn
    3. 1991611Domain d1py2c_: 1py2 C: [95321]
      complexed with a small molecule inhibitor
      complexed with frh, zn
    4. 1991612Domain d1py2d_: 1py2 D: [95322]
      complexed with a small molecule inhibitor
      complexed with frh, zn
  11. Domain(s) for 1qvn:
    1. 1991602Domain d1qvna_: 1qvn A: [161678]
      automated match to d1irla_
      complexed with fri, zn
    2. 1991603Domain d1qvnb_: 1qvn B: [161679]
      automated match to d1irla_
      complexed with fri, zn
    3. 1991604Domain d1qvnc_: 1qvn C: [161680]
      automated match to d1irla_
      complexed with fri, zn
    4. 1991605Domain d1qvnd_: 1qvn D: [161681]
      automated match to d1irla_
      complexed with fri, zn
  12. Domain(s) for 1z92:
  13. Domain(s) for 2b5i:
  14. Domain(s) for 2erj:
    1. 1991606Domain d2erjd_: 2erj D: [132294]
      Other proteins in same PDB: d2erja1, d2erja2, d2erjb1, d2erjb2, d2erjb3, d2erjc1, d2erjc2, d2erje1, d2erje2, d2erjf1, d2erjf2, d2erjf3, d2erjg1, d2erjg2
      automated match to d1irla_
      complexed with nag
    2. 1991607Domain d2erjh_: 2erj H: [132301]
      Other proteins in same PDB: d2erja1, d2erja2, d2erjb1, d2erjb2, d2erjb3, d2erjc1, d2erjc2, d2erje1, d2erje2, d2erjf1, d2erjf2, d2erjf3, d2erjg1, d2erjg2
      automated match to d1irla_
      complexed with nag
  15. Domain(s) for 3ink:
    1. 1991596Domain d3inkc_: 3ink C: [16881]
    2. 1991597Domain d3inkd_: 3ink D: [16882]
  16. Domain(s) for 3qb1:
    1. 1991613Domain d3qb1a_: 3qb1 A: [248836]
      automated match to d1irla_
      mutant
    2. 1991614Domain d3qb1b_: 3qb1 B: [248837]
      automated match to d1irla_
      mutant
    3. 1991615Domain d3qb1c_: 3qb1 C: [248838]
      automated match to d1irla_
      mutant
    4. 1991616Domain d3qb1d_: 3qb1 D: [248839]
      automated match to d1irla_
      mutant
    5. 1991617Domain d3qb1e_: 3qb1 E: [248840]
      automated match to d1irla_
      mutant
    6. 1991618Domain d3qb1f_: 3qb1 F: [248841]
      automated match to d1irla_
      mutant
    7. 1991619Domain d3qb1g_: 3qb1 G: [248842]
      automated match to d1irla_
      mutant
    8. 1991620Domain d3qb1h_: 3qb1 H: [248843]
      automated match to d1irla_
      mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.2 Interleukin-2 (IL-2)

Timeline for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.2 Interleukin-2 (IL-2):