SCOP 1.67: Protein: Interleukin-2 (IL-2)

Lineage for Protein: Interleukin-2 (IL-2)

Root: SCOP 1.67
Class a: All alpha proteins [46456] (202 folds)
Fold a.26: 4-helical cytokines [47265] (1 superfamily)
core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
Superfamily a.26.1: 4-helical cytokines [47266] (3 families)
there are two different topoisomers of this fold with different entanglements of the two crossover connections
Family a.26.1.2: Short-chain cytokines [47286] (11 proteins)
Protein Interleukin-2 (IL-2) [47301] (1 species)

Species:

Human (Homo sapiens) [TaxId:9606] [47302] (11 PDB entries)
1. Domain for 1irl:
  - Domain d1irl__: 1irl - [16883]
    mutant
2. Domain for 1m47:
  - Domain d1m47a_: 1m47 A: [74442]
    complexed with sul
3. Domains for 1m48:
  1. Domain d1m48a_: 1m48 A: [74443]
  2. Domain d1m48b_: 1m48 B: [74444]
    complexed with frg
4. Domains for 1m49:
  1. Domain d1m49a_: 1m49 A: [74445]
  2. Domain d1m49b_: 1m49 B: [74446]
    complexed with cmm
5. Domain for 1m4a:
  - Domain d1m4aa_: 1m4a A: [74447]
    complexed with gol, mpe; mutant
6. Domain for 1m4b:
  - Domain d1m4ba_: 1m4b A: [74448]
    complexed with nmp; mutant
7. Domains for 1m4c:
  1. Domain d1m4ca_: 1m4c A: [74449]
  2. Domain d1m4cb_: 1m4c B: [74450]
8. Domain for 1nbp:
  - Domain d1nbpa_: 1nbp A: [80392]
    complexed with mhc, sul; mutant
9. Domains for 1pw6:
  1. Domain d1pw6a_: 1pw6 A: [95200]
  2. Domain d1pw6b_: 1pw6 B: [95201]
    complexed with a small molecule inhibitor
    complexed with frb, so4
10. Domains for 1py2:
  1. Domain d1py2a_: 1py2 A: [95319]
  2. Domain d1py2b_: 1py2 B: [95320]
  3. Domain d1py2c_: 1py2 C: [95321]
  4. Domain d1py2d_: 1py2 D: [95322]
    complexed with a small molecule inhibitor
    complexed with frh, zn
11. Domains for 3ink:
  1. Domain d3inkc_: 3ink C: [16881]
  2. Domain d3inkd_: 3ink D: [16882]
    mutant

More info for Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines

Timeline for Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines:

Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines first appeared (with stable ids) in SCOP 1.55
Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines appears in SCOP 1.65
Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines appears in SCOP 1.69
Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines appears in the current release, SCOPe 2.08