SCOPe 2.08: Protein: Granulocyte-macrophage colony-stimulating factor (GM-CSF)

Lineage for Protein: Granulocyte-macrophage colony-stimulating factor (GM-CSF)

Root: SCOPe 2.08
Class a: All alpha proteins [46456] (290 folds)
Fold a.26: 4-helical cytokines [47265] (1 superfamily)
core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
there are two different topoisomers of this fold with different entanglements of the two crossover connections
Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)
Protein Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289] (1 species)

Species:

Human (Homo sapiens) [TaxId:9606] [47290] (10 PDB entries)

Domains for 1csg:
1. Domain d1csga1: 1csg A:5-110 [16851]
  Other proteins in same PDB: d1csga2, d1csgb2
2. Domain d1csgb1: 1csg B:5-110 [16852]
  Other proteins in same PDB: d1csga2, d1csgb2
Domains for 2gmf:
1. Domain d2gmfa1: 2gmf A:4-110 [16849]
  Other proteins in same PDB: d2gmfa2, d2gmfb2
2. Domain d2gmfb1: 2gmf B:4-110 [16850]
  Other proteins in same PDB: d2gmfa2, d2gmfb2
Domain for 4nkq:
- Domain d4nkqc1: 4nkq C:14-110 [409242]
  Other proteins in same PDB: d4nkqb1, d4nkqb2, d4nkqc2
  complexed with nag
Domain for 4rs1:
- Domain d4rs1a_: 4rs1 A: [279338]
  automated match to d1csga_
  complexed with gol, nag
Domains for 5c7x:
1. Domain d5c7xa1: 5c7x A:9-110 [278026]
  Other proteins in same PDB: d5c7xa2, d5c7xb2, d5c7xl1, d5c7xl2, d5c7xn1, d5c7xn2
  automated match to d2gmfa_
  complexed with peg, pg6, pge
2. Domain d5c7xb1: 5c7x B:9-110 [278027]
  Other proteins in same PDB: d5c7xa2, d5c7xb2, d5c7xl1, d5c7xl2, d5c7xn1, d5c7xn2
  automated match to d2gmfa_
  complexed with peg, pg6, pge
Domain for 5d70:
- Domain d5d70a1: 5d70 A:8-110 [278080]
  Other proteins in same PDB: d5d70a2, d5d70l1, d5d70l2
  automated match to d2gmfa_
  complexed with so4
Domain for 5d71:
- Domain d5d71a1: 5d71 A:9-110 [278077]
  Other proteins in same PDB: d5d71a2, d5d71l1, d5d71l2
  automated match to d1csga_
  complexed with peg, so4
Domains for 5d72:
1. Domain d5d72a1: 5d72 A:10-110 [278078]
  Other proteins in same PDB: d5d72a2, d5d72b2, d5d72l1, d5d72l2, d5d72n1, d5d72n2
  automated match to d1csga_
  complexed with peg
2. Domain d5d72b1: 5d72 B:8-110 [278079]
  Other proteins in same PDB: d5d72a2, d5d72b2, d5d72l1, d5d72l2, d5d72n1, d5d72n2
  automated match to d1csga_
  complexed with peg

Domains for 6bfq:

Domain d6bfqg1: 6bfq G:23-110 [357368]
Other proteins in same PDB: d6bfqa_, d6bfqb1, d6bfqb2, d6bfqc_, d6bfqd1, d6bfqd2, d6bfqe_, d6bfqf1, d6bfqf2, d6bfqg2, d6bfqh_, d6bfqi2, d6bfqj2, d6bfqk2, d6bfql1, d6bfql2
automated match to d5d22b_

Domain d6bfqi1: 6bfq I:23-110 [357362]
Other proteins in same PDB: d6bfqa_, d6bfqb1, d6bfqb2, d6bfqc_, d6bfqd1, d6bfqd2, d6bfqe_, d6bfqf1, d6bfqf2, d6bfqg2, d6bfqh_, d6bfqi2, d6bfqj2, d6bfqk2, d6bfql1, d6bfql2
automated match to d5d22b_

Domain d6bfqj1: 6bfq J:19-110 [357394]
Other proteins in same PDB: d6bfqa_, d6bfqb1, d6bfqb2, d6bfqc_, d6bfqd1, d6bfqd2, d6bfqe_, d6bfqf1, d6bfqf2, d6bfqg2, d6bfqh_, d6bfqi2, d6bfqj2, d6bfqk2, d6bfql1, d6bfql2
automated match to d5d22b_

Domain d6bfqk1: 6bfq K:19-110 [357336]
Other proteins in same PDB: d6bfqa_, d6bfqb1, d6bfqb2, d6bfqc_, d6bfqd1, d6bfqd2, d6bfqe_, d6bfqf1, d6bfqf2, d6bfqg2, d6bfqh_, d6bfqi2, d6bfqj2, d6bfqk2, d6bfql1, d6bfql2
automated match to d5d22b_

Domain for 6bfs:
- Domain d6bfsc1: 6bfs C:14-110 [357302]
  Other proteins in same PDB: d6bfsc2, d6bfsh_, d6bfsl1, d6bfsl2
  automated match to d5d22b_

More info for Protein Granulocyte-macrophage colony-stimulating factor (GM-CSF) from a.26.1.2: Short-chain cytokines

Timeline for Protein Granulocyte-macrophage colony-stimulating factor (GM-CSF) from a.26.1.2: Short-chain cytokines:

Protein Granulocyte-macrophage colony-stimulating factor (GM-CSF) from a.26.1.2: Short-chain cytokines first appeared (with stable ids) in SCOP 1.55
Protein Granulocyte-macrophage colony-stimulating factor (GM-CSF) from a.26.1.2: Short-chain cytokines appears in SCOPe 2.07