SCOP 1.75: Family a.26.1.2: Short-chain cytokines

Lineage for Family a.26.1.2: Short-chain cytokines

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (3 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (13 proteins)

Proteins:

1. Erythropoietin [47287] (1 species)
   long chain cytokine with a short-chain cytokine topology

   • Species Human (Homo sapiens) [TaxId:9606] [47288] (3 PDB entries)

2. Flt3 ligand [47297] (1 species)
   forms dimer similar to the M-CSF and SCF dimers

   • Species Human (Homo sapiens) [TaxId:9606] [47298] (1 PDB entry)

3. Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47290] (3 PDB entries)

4. Interleukin-13 (IL-13) [63532] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [63533] (3 PDB entries)

5. Interleukin-15 (IL-15) [158422] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [158423] (2 PDB entries)
      Uniprot P40933 49-162

   2. Species Mouse (Mus musculus) [TaxId:10090] [158424] (1 PDB entry)
      Uniprot P48346 49-162

6. Interleukin-2 (IL-2) [47301] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47302] (14 PDB entries)

7. Interleukin-21 (IL-21) [158425] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [158426] (1 PDB entry)
     Uniprot Q9HBE4 23-155

8. Interleukin-3 (IL-3) [47303] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47304] (1 PDB entry)

9. Interleukin-4 (IL-4) [47291] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47292] (16 PDB entries)

10. Interleukin-5 [47293] (1 species)
    intertwined dimer

    • Species Human (Homo sapiens) [TaxId:9606] [47294] (1 PDB entry)

11. Macrophage colony-stimulating factor (M-CSF) [47295] (1 species)
    forms dimer similar to the Flt3 ligand and SCF dimers

    • Species Human (Homo sapiens) [TaxId:9606] [47296] (1 PDB entry)

12. Stem cell factor, SCF [47299] (1 species)
    forms dimer similar to the M-CSF and Flt3 ligand dimers

    • Species Human (Homo sapiens) [TaxId:9606] [47300] (3 PDB entries)

13. Thrombopoietin [101140] (1 species)
    long chain cytokine with a short-chain cytokine topology

    • Species Human (Homo sapiens) [TaxId:9606] [101141] (2 PDB entries)

More info for Family a.26.1.2: Short-chain cytokines

Timeline for Family a.26.1.2: Short-chain cytokines:

• Family a.26.1.2: Short-chain cytokines first appeared (with stable ids) in SCOP 1.55
  
• Family a.26.1.2: Short-chain cytokines appears in SCOP 1.73
  
• Family a.26.1.2: Short-chain cytokines appears in SCOPe 2.01
  
• Family a.26.1.2: Short-chain cytokines appears in the current release, SCOPe 2.08