Lineage for Family a.26.1.2: Short-chain cytokines

  1. Root: SCOP 1.71
  2. 530466Class a: All alpha proteins [46456] (226 folds)
  3. 536620Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 536621Superfamily a.26.1: 4-helical cytokines [47266] (3 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 536689Family a.26.1.2: Short-chain cytokines [47286] (11 proteins)

Proteins:

  1. 536690Erythropoietin [47287] (1 species)
    long chain cytokine with a short-chain cytokine topology
  2. 536695Flt3 ligand [47297] (1 species)
    forms dimer similar to the M-CSF and SCF dimers
  3. 536701Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289] (1 species)
  4. 536707Interleukin-13 (IL-13) [63532] (1 species)
  5. 536712Interleukin-2 (IL-2) [47301] (1 species)
  6. 536733Interleukin-3 (IL-3) [47303] (1 species)
  7. 536736Interleukin-4 (IL-4) [47291] (1 species)
  8. 536751Interleukin-5 [47293] (1 species)
    intertwined dimer
  9. 536755Macrophage colony-stimulating factor (M-CSF) [47295] (1 species)
    forms dimer similar to the Flt3 ligand and SCF dimers
  10. 536759Stem cell factor, SCF [47299] (1 species)
    forms dimer similar to the M-CSF and Flt3 ligand dimers
  11. 536769Thrombopoietin [101140] (1 species)
    long chain cytokine with a short-chain cytokine topology

More info for Family a.26.1.2: Short-chain cytokines

Timeline for Family a.26.1.2: Short-chain cytokines: