SCOP 1.69: Species: Human (Homo sapiens)

Root: SCOP 1.69
Class a: All alpha proteins [46456] (218 folds)
Fold a.26: 4-helical cytokines [47265] (1 superfamily)
core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
Superfamily a.26.1: 4-helical cytokines [47266] (3 families)
there are two different topoisomers of this fold with different entanglements of the two crossover connections
Family a.26.1.1: Long-chain cytokines [47267] (9 proteins)
Protein Growth hormone, somatotropin [47276] (1 species)
Species Human (Homo sapiens) [TaxId:9606] [47277] (9 PDB entries)

Domain(s) for 1a22:
- Domain d1a22a_: 1a22 A: [16833]
  Other proteins in same PDB: d1a22b1, d1a22b2
Domain(s) for 1axi:
- Domain d1axia_: 1axi A: [16832]
  Other proteins in same PDB: d1axib1, d1axib2
Domain(s) for 1bp3:
- Domain d1bp3a_: 1bp3 A: [16838]
  Other proteins in same PDB: d1bp3b1, d1bp3b2
Domain(s) for 1hgu:
- Domain d1hgu__: 1hgu - [16837]
Domain(s) for 1huw:
- Domain d1huw__: 1huw - [16831]
Domain(s) for 1hwg:
- Domain d1hwga_: 1hwg A: [16834]
  Other proteins in same PDB: d1hwgb1, d1hwgb2, d1hwgc1, d1hwgc2
Domain(s) for 1hwh:
- Domain d1hwha_: 1hwh A: [16836]
  Other proteins in same PDB: d1hwhb1, d1hwhb2
Domain(s) for 1kf9:
1. Domain d1kf9a_: 1kf9 A: [77351]
  Other proteins in same PDB: d1kf9b1, d1kf9b2, d1kf9c1, d1kf9c2, d1kf9e1, d1kf9e2, d1kf9f1, d1kf9f2
2. Domain d1kf9d_: 1kf9 D: [77356]
  Other proteins in same PDB: d1kf9b1, d1kf9b2, d1kf9c1, d1kf9c2, d1kf9e1, d1kf9e2, d1kf9f1, d1kf9f2
  phage display derived variant
Domain(s) for 3hhr:
- Domain d3hhra_: 3hhr A: [16835]
  Other proteins in same PDB: d3hhrb1, d3hhrb2, d3hhrc1, d3hhrc2

Timeline for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Growth hormone, somatotropin:

Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Growth hormone, somatotropin first appeared (with stable ids) in SCOP 1.55
Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Growth hormone, somatotropin appears in SCOP 1.67
Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Growth hormone, somatotropin appears in SCOP 1.71
Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Growth hormone, somatotropin appears in the current release, SCOPe 2.08