Lineage for Superfamily a.26.1: 4-helical cytokines

  1. Root: SCOP 1.65
  2. 275720Class a: All alpha proteins [46456] (179 folds)
  3. 280090Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 280091Superfamily a.26.1: 4-helical cytokines [47266] (3 families) (S)
    there are two different topoisomers of this fold with different entanglments of the two crossover connections

Families:

  1. 280092a.26.1.1: Long-chain cytokines [47267] (9 proteins)
  2. 280157a.26.1.2: Short-chain cytokines [47286] (10 proteins)
  3. 280231a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (8 proteins)
    contains an additional helix in one of the crossover connections

More info for Superfamily a.26.1: 4-helical cytokines

Timeline for Superfamily a.26.1: 4-helical cytokines: