Lineage for Fold a.24: Four-helical up-and-down bundle

  1. Root: SCOPe 2.03
  2. 1253684Class a: All alpha proteins [46456] (284 folds)
  3. 1263159Fold a.24: Four-helical up-and-down bundle [47161] (28 superfamilies)
    core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Superfamilies:

  1. 1263160a.24.1: Apolipoprotein [47162] (1 family) (S)
  2. 1263178a.24.2: Aspartate receptor, ligand-binding domain [47170] (1 family) (S)
    automatically mapped to Pfam PF02203
  3. 1263194a.24.3: Cytochromes [47175] (2 families) (S)
    Heme-containing proteins
  4. 1263405a.24.4: Hemerythrin-like [47188] (1 family) (S)
  5. 1263449a.24.5: TMV-like viral coat proteins [47195] (1 family) (S)
    automatically mapped to Pfam PF00721
  6. 1263467a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family) (S)
    automatically mapped to Pfam PF08771
  7. 1263485a.24.8: Proteasome activator [47216] (1 family) (S)
  8. 1263535a.24.9: alpha-catenin/vinculin-like [47220] (2 families) (S)
  9. 1263608a.24.10: Histidine-containing phosphotransfer domain, HPT domain [47226] (7 families) (S)
    contains additional, fifth helix at the N-terminus
  10. 1263676a.24.11: Bacterial GAP domain [47233] (1 family) (S)
    contains extra helices in the loops at one end of the bundle
  11. 1263691a.24.12: Outer surface protein C (OspC) [63515] (2 families) (S)
  12. 1263719a.24.13: Domain of the SRP/SRP receptor G-proteins [47364] (2 families) (S)
  13. 1263787a.24.14: FAT domain of focal adhesion kinase [68993] (2 families) (S)
  14. 1263825a.24.15: FAD-dependent thiol oxidase [69000] (2 families) (S)
  15. 1263867a.24.16: Nucleotidyltransferase substrate binding subunit/domain [81593] (5 families) (S)
  16. 1263910a.24.17: Group V grass pollen allergen [81736] (1 family) (S)
  17. 1263931a.24.18: Oxygen-evolving enhancer protein 3, [101112] (1 family) (S)
    automatically mapped to Pfam PF05757
  18. 1263936a.24.19: Flagellar export chaperone FliS [101116] (2 families) (S)
    can form closed, open and helix-swapped bundles
  19. 1263955a.24.20: Colicin D immunity protein [101125] (1 family) (S)
    automatically mapped to Pfam PF09204
  20. 1263964a.24.21: RecG, N-terminal domain [69008] (1 family) (S)
  21. 1263969a.24.22: Nickel-containing superoxide dismutase, NiSOD [109770] (1 family) (S)
    automatically mapped to Pfam PF09055
  22. 1264057a.24.23: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [109775] (1 family) (S)
    contains extra alpha+beta subdomain formed by the N- and C-termini.
    automatically mapped to Pfam PF03036
  23. 1264062a.24.24: Domain from hypothetical 2610208m17rik protein [109779] (1 family) (S)
    automatically mapped to Pfam PF08910
  24. 1264067a.24.25: TrmE connector domain [116878] (1 family) (S)
  25. 1264073a.24.26: YppE-like [140415] (1 family) (S)
    flattened bundle at one end with helices 2 and coming in contact and separating helices 1 and 3
    automatically mapped to Pfam PF08807
  26. 1264086a.24.27: MW0975(SA0943)-like [140423] (1 family) (S)
    open bundle; there is a long groove between helices 1 and 4
    automatically mapped to Pfam PF10368
  27. 1264091a.24.28: VPS28 C-terminal domain-like [140427] (2 families) (S)
  28. 1264112a.24.29: TM1646-like [158397] (2 families) (S)
    automatically mapped to Pfam PF03885

More info for Fold a.24: Four-helical up-and-down bundle

Timeline for Fold a.24: Four-helical up-and-down bundle: