Lineage for Fold a.24: Four-helical up-and-down bundle

  1. Root: SCOP 1.75
  2. 758332Class a: All alpha proteins [46456] (284 folds)
  3. 765368Fold a.24: Four-helical up-and-down bundle [47161] (28 superfamilies)
    core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Superfamilies:

  1. 765369a.24.1: Apolipoprotein [47162] (1 family) (S)
  2. 765387a.24.2: Aspartate receptor, ligand-binding domain [47170] (1 family) (S)
  3. 765403a.24.3: Cytochromes [47175] (2 families) (S)
    Heme-containing proteins
  4. 765456a.24.4: Hemerythrin-like [47188] (1 family) (S)
  5. 765500a.24.5: TMV-like viral coat proteins [47195] (1 family) (S)
  6. 765515a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family) (S)
  7. 765527a.24.8: Proteasome activator [47216] (1 family) (S)
  8. 765561a.24.9: alpha-catenin/vinculin-like [47220] (2 families) (S)
  9. 765604a.24.10: Histidine-containing phosphotransfer domain, HPT domain [47226] (6 families) (S)
    contains additional, fifth helix at the N-terminus
  10. 765665a.24.11: Bacterial GAP domain [47233] (1 family) (S)
    contains extra helices in the loops at one end of the bundle
  11. 765680a.24.12: Outer surface protein C (OspC) [63515] (1 family) (S)
  12. 765693a.24.13: Domain of the SRP/SRP receptor G-proteins [47364] (1 family) (S)
  13. 765756a.24.14: FAT domain of focal adhesion kinase [68993] (1 family) (S)
  14. 765783a.24.15: FAD-dependent thiol oxidase [69000] (1 family) (S)
  15. 765799a.24.16: Nucleotidyltransferase substrate binding subunit/domain [81593] (4 families) (S)
  16. 765838a.24.17: Group V grass pollen allergen [81736] (1 family) (S)
  17. 765859a.24.18: Oxygen-evolving enhancer protein 3, [101112] (1 family) (S)
  18. 765864a.24.19: Flagellar export chaperone FliS [101116] (1 family) (S)
    can form closed, open and helix-swapped bundles
  19. 765876a.24.20: Colicin D immunity protein [101125] (1 family) (S)
  20. 765883a.24.21: RecG, N-terminal domain [69008] (1 family) (S)
  21. 765888a.24.22: Nickel-containing superoxide dismutase, NiSOD [109770] (1 family) (S)
  22. 765965a.24.23: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [109775] (1 family) (S)
    contains extra alpha+beta subdomain formed by the N- and C-termini.
  23. 765970a.24.24: Domain from hypothetical 2610208m17rik protein [109779] (1 family) (S)
  24. 765975a.24.25: TrmE connector domain [116878] (1 family) (S)
  25. 765981a.24.26: YppE-like [140415] (1 family) (S)
    flattened bundle at one end with helices 2 and coming in contact and separating helices 1 and 3
  26. 765994a.24.27: MW0975(SA0943)-like [140423] (1 family) (S)
    open bundle; there is a long groove between helices 1 and 4
  27. 765999a.24.28: VPS28 C-terminal domain-like [140427] (1 family) (S)
  28. 766013a.24.29: TM1646-like [158397] (1 family) (S)

More info for Fold a.24: Four-helical up-and-down bundle

Timeline for Fold a.24: Four-helical up-and-down bundle: