Lineage for Fold a.24: Four-helical up-and-down bundle

  1. Root: SCOP 1.73
  2. 631650Class a: All alpha proteins [46456] (258 folds)
  3. 637916Fold a.24: Four-helical up-and-down bundle [47161] (27 superfamilies)
    core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Superfamilies:

  1. 637917a.24.1: Apolipoprotein [47162] (1 family) (S)
  2. 637935a.24.2: Aspartate receptor, ligand-binding domain [47170] (1 family) (S)
  3. 637951a.24.3: Cytochromes [47175] (2 families) (S)
    Heme-containing proteins
  4. 638000a.24.4: Hemerythrin [47188] (1 family) (S)
  5. 638044a.24.5: TMV-like viral coat proteins [47195] (1 family) (S)
  6. 638058a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family) (S)
  7. 638070a.24.8: Proteasome activator reg(alpha) [47216] (1 family) (S)
  8. 638081a.24.9: alpha-catenin/vinculin-like [47220] (2 families) (S)
  9. 638124a.24.10: Histidine-containing phosphotransfer domain, HPT domain [47226] (5 families) (S)
    contains additional, fifth helix at the N-terminus
  10. 638179a.24.11: Bacterial GAP domain [47233] (1 family) (S)
    contains extra helices in the loops at one end of the bundle
  11. 638194a.24.12: Outer surface protein C (OspC) [63515] (1 family) (S)
  12. 638207a.24.13: Domain of the SRP/SRP receptor G-proteins [47364] (1 family) (S)
  13. 638269a.24.14: FAT domain of focal adhesion kinase [68993] (1 family) (S)
  14. 638292a.24.15: FAD-dependent thiol oxidase [69000] (1 family) (S)
  15. 638308a.24.16: Nucleotidyltransferase substrate binding subunit/domain [81593] (4 families) (S)
  16. 638343a.24.17: Group V grass pollen allergen [81736] (1 family) (S)
  17. 638364a.24.18: Oxygen-evolving enhancer protein 3, [101112] (1 family) (S)
  18. 638369a.24.19: Flagellar export chaperone FliS [101116] (1 family) (S)
    can form closed, open and helix-swapped bundles
  19. 638381a.24.20: Colicin D immunity protein [101125] (1 family) (S)
  20. 638388a.24.21: RecG, N-terminal domain [69008] (1 family) (S)
  21. 638393a.24.22: Nickel-containing superoxide dismutase, NiSOD [109770] (1 family) (S)
  22. 638470a.24.23: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [109775] (1 family) (S)
    contains extra alpha+beta subdomain formed by the N- and C-termini.
  23. 638475a.24.24: Domain from hypothetical 2610208m17rik protein [109779] (1 family) (S)
  24. 638480a.24.25: TrmE connector domain [116878] (1 family) (S)
  25. 638486a.24.26: YppE-like [140415] (1 family) (S)
    flattened bundle at one end with helices 2 and coming in contact and separating helices 1 and 3
  26. 638499a.24.27: MW0975(SA0943)-like [140423] (1 family) (S)
    open bundle; there is a long groove between helices 1 and 4
  27. 638504a.24.28: VPS28 C-terminal domain-like [140427] (1 family) (S)

More info for Fold a.24: Four-helical up-and-down bundle

Timeline for Fold a.24: Four-helical up-and-down bundle: