SCOP 1.67: Fold a.24: Four-helical up-and-down bundle

Lineage for Fold a.24: Four-helical up-and-down bundle

1. Root: SCOP 1.67

2. Class a: All alpha proteins [46456] (202 folds)

3. Fold a.24: Four-helical up-and-down bundle [47161] (20 superfamilies)
   core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Superfamilies:

1. a.24.1: Apolipoprotein [47162] (1 family)

2. a.24.2: Aspartate receptor, ligand-binding domain [47170] (1 family)

3. a.24.3: Cytochromes [47175] (2 families)
   Heme-containing proteins

4. a.24.4: Hemerythrin [47188] (1 family)

5. a.24.5: TMV-like viral coat proteins [47195] (1 family)

6. a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family)

7. a.24.8: Proteasome activator reg(alpha) [47216] (1 family)

8. a.24.9: alpha-catenin/vinculin [47220] (1 family)

9. a.24.10: Histidine-containing phosphotransfer domain, HPT domain [47226] (3 families)
   contains additional, fifth helix at the N-terminus

10. a.24.11: Bacterial GAP domain [47233] (1 family)
    contains extra helices in the loops at one end of the bundle

11. a.24.12: Outer surface protein C (OspC) [63515] (1 family)

12. a.24.13: Domain of the SRP/SRP receptor G-proteins [47364] (1 family)

13. a.24.14: FAT domain of focal adhesion kinase [68993] (1 family)

14. a.24.15: FAD-dependent thiol oxidase [69000] (1 family)

15. a.24.16: Nucleotidyltransferase substrate binding subunit/domain [81593] (3 families)

16. a.24.17: Group V grass pollen allergen [81736] (1 family)

17. a.24.18: Oxygen-evolving enhancer protein 3, [101112] (1 family)

18. a.24.19: Flagellar export chaperone FliS [101116] (1 family)
    can form closed, open and helix-swapped bundles

19. a.24.20: Colicin D immunity protein [101125] (1 family)

20. a.24.21: RecG, N-terminal domain [69008] (1 family)

More info for Fold a.24: Four-helical up-and-down bundle

Timeline for Fold a.24: Four-helical up-and-down bundle:

• Fold a.24: Four-helical up-and-down bundle first appeared (with stable ids) in SCOP 1.55
  
• Fold a.24: Four-helical up-and-down bundle appears in SCOP 1.65
  
• Fold a.24: Four-helical up-and-down bundle appears in SCOP 1.69
  
• Fold a.24: Four-helical up-and-down bundle appears in the current release, SCOPe 2.08