SCOP 1.63: Family a.22.1.3: TBP-associated factors, TAFs

Lineage for Family a.22.1.3: TBP-associated factors, TAFs

1. Root: SCOP 1.63

2. Class a: All alpha proteins [46456] (171 folds)

3. Fold a.22: Histone-fold [47112] (1 superfamily)
   core: 3 helices; long middle helix is flanked at each end with shorter ones

4. Superfamily a.22.1: Histone-fold [47113] (3 families)

5. Family a.22.1.3: TBP-associated factors, TAFs [47134] (10 proteins)

Proteins:

1. Negative cofactor 2, NC2, alpha chain [63507] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [63508] (1 PDB entry)

2. Negative cofactor 2, NC2, beta chain [63509] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [63510] (1 PDB entry)

3. Nuclear transcription factor Y subunit beta (Nf-Yb3) [81724] (1 species)
   forms a heterodimer with Nf-Yc2 similar to H2A/H2B

   • Species Human (Homo sapiens) [TaxId:9606] [81725] (1 PDB entry)

4. Nuclear transcription factor Y subunit gamma (Nf-Yc2) [81726] (1 species)
   forms a heterodimer with Nf-Yb3 similar to H2A/H2B

   • Species Human (Homo sapiens) [TaxId:9606] [81727] (1 PDB entry)

5. TAF(II)-135, (TAF(II)-130, hTAF4), histone fold domain [81720] (1 species)
   lacks the third helix, forms a heterodimer with TAF(II)-20 similar to H2A-H2B

   • Species Human (Homo sapiens) [TaxId:9606] [81721] (1 PDB entry)

6. TAF(II)-20, (TAF(II)-15, hTAF12), histone fold domain [81722] (1 species)
   forms a heterodimer with TAF(II)-135 similar to H2A-H2B

   • Species Human (Homo sapiens) [TaxId:9606] [81723] (1 PDB entry)

7. TAF(II)18 [47139] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47140] (2 PDB entries)

8. TAF(II)28 [47141] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47142] (2 PDB entries)

9. TAF(II)42 [47135] (1 species)
   TAFii42 and TAFii62 form heterotetramer similar to (H3-H4)2

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [47136] (1 PDB entry)

10. TAF(II)62 [47137] (1 species)
    TAFii42 and TAFii62 form heterotetramer similar to (H3-H4)2

    • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [47138] (1 PDB entry)

More info for Family a.22.1.3: TBP-associated factors, TAFs

Timeline for Family a.22.1.3: TBP-associated factors, TAFs:

• Family a.22.1.3: TBP-associated factors, TAFs first appeared (with stable ids) in SCOP 1.55
  
• Family a.22.1.3: TBP-associated factors, TAFs appears in SCOP 1.61
  
• Family a.22.1.3: TBP-associated factors, TAFs appears in SCOP 1.65
  
• Family a.22.1.3: TBP-associated factors, TAFs appears in the current release, SCOPe 2.08