SCOPe 2.03: Family a.22.1.1: Nucleosome core histones

Lineage for Family a.22.1.1: Nucleosome core histones

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.22: Histone-fold [47112] (1 superfamily)
   core: 3 helices; long middle helix is flanked at each end with shorter ones

4. Superfamily a.22.1: Histone-fold [47113] (5 families)

5. Family a.22.1.1: Nucleosome core histones [47114] (6 proteins)
   form octamers composed of two copies of each of the four histones

Proteins:

1. Histone H2A [47115] (6 species)

   1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [47117] (34 PDB entries)

   2. Species Baker's yeast (Saccharomyces cerevisiae), H2A.1 [TaxId:4932] [68984] (2 PDB entries)

   3. Species Chicken (Gallus gallus), erythrocytes [TaxId:9031] [47116] (6 PDB entries)
      Uniprot P02263

   4. Species Human (Homo sapiens), H2A.a [TaxId:9606] [140392] (1 PDB entry)
      Uniprot P28001 11-118

   5. Species Human (Homo sapiens), variant H2A.Z [TaxId:9606] [47118] (1 PDB entry)

   6. Species Mouse (Mus musculus), H2A.1 [TaxId:10090] [158384] (1 PDB entry)
      Uniprot P22752 14-118

2. Histone H2B [47119] (6 species)

   1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [47121] (35 PDB entries)

   2. Species Baker's yeast (Saccharomyces cerevisiae), H2B.2 [TaxId:4932] [68985] (2 PDB entries)

   3. Species Chicken (Gallus gallus), erythrocytes [TaxId:9031] [47120] (6 PDB entries)
      Uniprot P02279

   4. Species Human (Homo sapiens), H2B.k [TaxId:9606] [140394] (1 PDB entry)
      Uniprot O60814 30-125

   5. Species Mouse (Mus musculus), H2Ba [TaxId:10090] [140393] (2 PDB entries)
      Uniprot Q9D2U9 34-126

   6. Species Xenopus (Silurana) tropicalis [TaxId:8364] [158385] (2 PDB entries)

3. Histone H3 [47122] (6 species)

   1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [47124] (39 PDB entries)

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [68986] (1 PDB entry)

   3. Species Chicken (Gallus gallus), erythrocytes [TaxId:9031] [47123] (6 PDB entries)
      Uniprot P84229

   4. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [158386] (1 PDB entry)

   5. Species Human (Homo sapiens) [TaxId:9606] [187038] (10 PDB entries)

   6. Species Mouse (Mus musculus), H3.1 [TaxId:10090] [140395] (1 PDB entry)
      Uniprot P68433 38-135

4. Histone H4 [47125] (7 species)

   1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [47127] (38 PDB entries)

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [68987] (1 PDB entry)

   3. Species Chicken (Gallus gallus), erythrocytes [TaxId:9031] [47126] (6 PDB entries)
      Uniprot P62801

   4. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [158387] (2 PDB entries)

   5. Species Human (Homo sapiens) [TaxId:9606] [192456] (11 PDB entries)

   6. Species Kluyveromyces lactis [TaxId:284590] [189974] (1 PDB entry)

   7. Species Mouse (Mus musculus) [TaxId:10090] [47128] (2 PDB entries)

5. macro-H2A.1, histone domain [140396] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [140397] (2 PDB entries)
     Uniprot O75367 11-116

6. automated matches [193445] (4 species)
   not a true protein

   1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [225181] (3 PDB entries)

   2. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [225310] (2 PDB entries)

   3. Species Human (Homo sapiens) [TaxId:9606] [193446] (18 PDB entries)

   4. Species Kluyveromyces lactis [TaxId:284590] [226140] (2 PDB entries)

More info for Family a.22.1.1: Nucleosome core histones

Timeline for Family a.22.1.1: Nucleosome core histones:

• Family a.22.1.1: Nucleosome core histones first appeared (with stable ids) in SCOP 1.55
  
• Family a.22.1.1: Nucleosome core histones appears in SCOPe 2.02
  
• Family a.22.1.1: Nucleosome core histones appears in SCOPe 2.04
  
• Family a.22.1.1: Nucleosome core histones appears in the current release, SCOPe 2.08