Lineage for Family a.22.1.1: Nucleosome core histones

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1986516Fold a.22: Histone-fold [47112] (1 superfamily)
    core: 3 helices; long middle helix is flanked at each end with shorter ones
  4. 1986517Superfamily a.22.1: Histone-fold [47113] (5 families) (S)
  5. 1986518Family a.22.1.1: Nucleosome core histones [47114] (6 protein domains)
    form octamers composed of two copies of each of the four histones

Protein Domains:

  1. 1986519Histone H2A [47115] (6 species)
    1. 1986520Species African clawed frog (Xenopus laevis) [TaxId:8355] [47117] (34 PDB entries)
    2. 1986591Species Baker's yeast (Saccharomyces cerevisiae), H2A.1 [TaxId:4932] [68984] (2 PDB entries)
    3. 1986595Species Chicken (Gallus gallus), erythrocytes [TaxId:9031] [47116] (6 PDB entries)
      Uniprot P02263
    4. 1986606Species Human (Homo sapiens), H2A.a [TaxId:9606] [140392] (1 PDB entry)
      Uniprot P28001 11-118
    5. 1986609Species Human (Homo sapiens), variant H2A.Z [TaxId:9606] [47118] (1 PDB entry)
    6. 1986612Species Mouse (Mus musculus), H2A.1 [TaxId:10090] [158384] (1 PDB entry)
      Uniprot P22752 14-118
  2. 1986614Histone H2B [47119] (6 species)
    1. 1986615Species African clawed frog (Xenopus laevis) [TaxId:8355] [47121] (39 PDB entries)
    2. 1986686Species Baker's yeast (Saccharomyces cerevisiae), H2B.2 [TaxId:4932] [68985] (2 PDB entries)
    3. 1986690Species Chicken (Gallus gallus), erythrocytes [TaxId:9031] [47120] (6 PDB entries)
      Uniprot P02279
    4. 1986701Species Human (Homo sapiens), H2B.k [TaxId:9606] [140394] (1 PDB entry)
      Uniprot O60814 30-125
    5. 1986704Species Mouse (Mus musculus), H2Ba [TaxId:10090] [140393] (2 PDB entries)
      Uniprot Q9D2U9 34-126
    6. 1986707Species Western clawed frog (Xenopus tropicalis) [TaxId:8364] [158385] (2 PDB entries)
  3. 1986712Histone H3 [47122] (6 species)
    1. 1986713Species African clawed frog (Xenopus laevis) [TaxId:8355] [47124] (39 PDB entries)
    2. 1986793Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [68986] (1 PDB entry)
    3. 1986796Species Chicken (Gallus gallus), erythrocytes [TaxId:9031] [47123] (6 PDB entries)
      Uniprot P84229
    4. 1986807Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [158386] (2 PDB entries)
    5. 1986811Species Human (Homo sapiens) [TaxId:9606] [187038] (10 PDB entries)
    6. 1986829Species Mouse (Mus musculus), H3.1 [TaxId:10090] [140395] (1 PDB entry)
      Uniprot P68433 38-135
  4. 1986832Histone H4 [47125] (7 species)
    1. 1986833Species African clawed frog (Xenopus laevis) [TaxId:8355] [47127] (57 PDB entries)
    2. 1986910Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [68987] (1 PDB entry)
    3. 1986913Species Chicken (Gallus gallus), erythrocytes [TaxId:9031] [47126] (6 PDB entries)
      Uniprot P62801
    4. 1986924Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [158387] (2 PDB entries)
    5. 1986931Species Human (Homo sapiens) [TaxId:9606] [192456] (15 PDB entries)
    6. 1986949Species Kluyveromyces lactis [TaxId:284590] [189974] (1 PDB entry)
    7. 1986951Species Mouse (Mus musculus) [TaxId:10090] [47128] (1 PDB entry)
  5. 1986954macro-H2A.1, histone domain [140396] (1 species)
  6. 1986958automated matches [193445] (6 species)
    not a true protein
    1. 1986959Species African clawed frog (Xenopus laevis) [TaxId:8355] [225181] (8 PDB entries)
    2. 1986964Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [256335] (4 PDB entries)
    3. 1986983Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [225310] (17 PDB entries)
    4. 1986993Species Human (Homo sapiens) [TaxId:9606] [193446] (46 PDB entries)
    5. 1987099Species Kluyveromyces lactis [TaxId:284590] [226140] (2 PDB entries)
    6. 1987109Species Mouse (Mus musculus) [TaxId:10090] [254907] (3 PDB entries)

More info for Family a.22.1.1: Nucleosome core histones

Timeline for Family a.22.1.1: Nucleosome core histones: