SCOP 1.65: Family a.4.1.1: Homeodomain

Lineage for Family a.4.1.1: Homeodomain

1. Root: SCOP 1.65

2. Class a: All alpha proteins [46456] (179 folds)

3. Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (12 superfamilies)
   core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

4. Superfamily a.4.1: Homeodomain-like [46689] (11 families)
   consists only of helices

5. Family a.4.1.1: Homeodomain [46690] (21 proteins)

Proteins:

1. Antennapedia Homeodomain [46716] (1 species)

   • Species Drosophila melanogaster [TaxId:7227] [46717] (5 PDB entries)

2. Engrailed Homeodomain [46691] (1 species)

   • Species Drosophila melanogaster [TaxId:7227] [46692] (5 PDB entries)

3. Even-skipped homeodomain [63465] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [63466] (1 PDB entry)

4. Extradenticle (exd) homeodomain [46720] (1 species)

   • Species Drosophila melanogaster [TaxId:7227] [46721] (1 PDB entry)

5. Fushi Tarazu protein [46722] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [46723] (1 PDB entry)

6. Hepatocyte nuclear factor 1a (LFB1/HNF1) [46697] (2 species)
   atypical Homeodomain with a large insertion into HTH motif

   1. Species Human (Homo sapiens) [TaxId:9606] [81680] (1 PDB entry)

   2. Species Rat (Rattus rattus) [TaxId:10117] [46698] (2 PDB entries)

7. Homeo-prospero domain of Prospero protein [81681] (1 species)
   single domain composed of a homeodomain-homology N-terminal region (1245-1295) and the prospero-specific C-terminal region (1296-1396) that forms a 4-helical bundle

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [81682] (1 PDB entry)

8. Homeobox protein hox-b1 [46709] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [46710] (1 PDB entry)

9. Insulin gene enhancer protein isl-1 [46714] (1 species)

   • Species Rat (Rattus norvegicus) [TaxId:10116] [46715] (1 PDB entry)

10. mat alpha2 Homeodomain [46695] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [46696] (6 PDB entries)

11. Mating type protein A1 Homeodomain [46693] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [46694] (6 PDB entries)

12. Msx-1 homeodomain [63463] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [63464] (1 PDB entry)

13. Oct-1 POU Homeodomain [46699] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [46700] (6 PDB entries)

14. Oct-2 POU Homeodomain [46705] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [46706] (1 PDB entry)

15. Oct-3 POU Homeodomain [46707] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [46708] (1 PDB entry)

16. Paired protein [46726] (1 species)

    • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [46727] (1 PDB entry)

17. pbx1 [46711] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [46712] (1 PDB entry)

    2. Species Mouse (Mus musculus) [TaxId:10090] [46713] (2 PDB entries)

18. Pit-1 POU homeodomain [46701] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [46702] (1 PDB entry)

19. Thyroid transcription factor 1 homeodomain [46703] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [46704] (1 PDB entry)

20. Ultrabithorax (ubx) homeodomain [46718] (1 species)

    • Species Drosophila melanogaster [TaxId:7227] [46719] (1 PDB entry)

21. VND/NK-2 protein [46724] (1 species)

    • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [46725] (4 PDB entries)

More info for Family a.4.1.1: Homeodomain

Timeline for Family a.4.1.1: Homeodomain:

• Family a.4.1.1: Homeodomain first appeared (with stable ids) in SCOP 1.55
  
• Family a.4.1.1: Homeodomain appears in SCOP 1.63
  
• Family a.4.1.1: Homeodomain appears in SCOP 1.67
  
• Family a.4.1.1: Homeodomain appears in the current release, SCOPe 2.08