Lineage for Family a.4.1.1: Homeodomain

  1. Root: SCOPe 2.08
  2. Class a: All alpha proteins [46456] (290 folds)
  3. Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  4. Superfamily a.4.1: Homeodomain-like [46689] (21 families) (S)
    consists only of helices
  5. Family a.4.1.1: Homeodomain [46690] (41 proteins)
    Pfam PF00046

Proteins:

  1. Antennapedia Homeodomain [46716] (1 species)
  2. DNA-binding protein SATB2 [116776] (1 species)
  3. Engrailed Homeodomain [46691] (1 species)
  4. Even-skipped homeodomain [63465] (1 species)
  5. Extradenticle (exd) homeodomain [46720] (1 species)
  6. Fushi Tarazu protein [46722] (1 species)
  7. Hepatocyte nuclear factor 1a (LFB1/HNF1) [46697] (2 species)
    atypical Homeodomain with a large insertion into HTH motif
    1. Species Human (Homo sapiens) [TaxId:9606] [81680] (1 PDB entry)
    2. Species Rat (Rattus rattus) [TaxId:10117] [46698] (2 PDB entries)
  8. Hepatocyte nuclear factor 6 [116780] (1 species)
  9. Homeo-prospero domain of Prospero protein [81681] (1 species)
    single domain composed of a homeodomain-homology N-terminal region (1245-1295) and the prospero-specific C-terminal region (1296-1396) that forms a 4-helical bundle
  10. Homeobox protein hox-a9 [100994] (1 species)
  11. Homeobox protein hox-b1 [46709] (1 species)
  12. Homeobox protein hox-b13 [140161] (1 species)
  13. Homeobox protein pknox1 [140153] (1 species)
  14. Homeobox protein prh [140149] (1 species)
  15. Homeobox-containing protein 1, HMBOX1 (Flj21616) [140159] (1 species)
  16. Homeobox-leucine zipper protein Homez [116778] (1 species)
  17. Homeodomain-only protein, Hop [109647] (1 species)
  18. Homeotic bicoid protein [140155] (1 species)
  19. Hypothetical protein 4930532d21rik [140157] (1 species)
  20. Insulin gene enhancer protein isl-1 [46714] (1 species)
  21. LAG1 longevity assurance homolog 5, LASS5 [140141] (1 species)
  22. Lag1 longevity assurance homolog 6, LASS6 [140147] (1 species)
  23. mat alpha2 Homeodomain [46695] (1 species)
  24. Mating type protein A1 Homeodomain [46693] (1 species)
  25. Msx-1 homeodomain [63463] (1 species)
  26. Oct-1 POU Homeodomain [46699] (1 species)
  27. Oct-2 POU Homeodomain [46705] (1 species)
  28. Oct-3 POU Homeodomain [46707] (1 species)
  29. Paired box protein pax6 [140143] (1 species)
  30. Paired protein [46726] (1 species)
  31. pbx1 [46711] (2 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [46712] (2 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [46713] (2 PDB entries)
  32. Pit-1 POU homeodomain [46701] (1 species)
  33. Pituitary homeobox 2 [140151] (1 species)
  34. Thyroid transcription factor 1 homeodomain [46703] (1 species)
  35. Transcriptional adaptor 2-like, TADA2L, isoform b [140145] (1 species)
  36. Ultrabithorax (ubx) homeodomain [46718] (1 species)
  37. VND/NK-2 protein [46724] (1 species)
  38. ZF-HD homeobox protein At4g24660 [116774] (1 species)
  39. ZF-HD homeobox protein At5g65410 [116772] (1 species)
  40. Zinc fingers and homeoboxes protein 1, ZHX1 [158242] (1 species)
  41. automated matches [190360] (3 species)
    not a true protein
    1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [187191] (6 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [188758] (10 PDB entries)
    3. Species Mouse (Mus musculus) [TaxId:10090] [255210] (1 PDB entry)

More info for Family a.4.1.1: Homeodomain

Timeline for Family a.4.1.1: Homeodomain: