Lineage for Superfamily a.4.1: Homeodomain-like

  1. Root: SCOPe 2.08
  2. Class a: All alpha proteins [46456] (290 folds)
  3. Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  4. Superfamily a.4.1: Homeodomain-like [46689] (21 families) (S)
    consists only of helices

Families:

  1. a.4.1.1: Homeodomain [46690] (41 proteins)
    Pfam PF00046
  2. a.4.1.2: Recombinase DNA-binding domain [46728] (5 proteins)
  3. a.4.1.3: Myb/SANT domain [46739] (16 proteins)
  4. a.4.1.4: DNA-binding domain of telomeric protein [46745] (3 proteins)
    part of Pfam PF00249 (Myb/SANT domain)
  5. a.4.1.5: Paired domain [46748] (3 proteins)
    duplication: consists of two domains of this fold
  6. a.4.1.6: DNA-binding domain of rap1 [46753] (3 proteins)
    duplication: consist of two domains of this fold
  7. a.4.1.7: Centromere-binding [46756] (2 proteins)
    duplication: tandem repeat of two similar domains
  8. a.4.1.8: AraC type transcriptional activator [46759] (2 proteins)
    duplication: consists of two structural repeats bipartite HTH protein
  9. a.4.1.9: Tetracyclin repressor-like, N-terminal domain [46764] (35 proteins)
  10. a.4.1.11: GARP response regulators [81683] (1 protein)
    plant myb-related DNA-binding motif
    automatically mapped to Pfam PF00249
  11. a.4.1.12: FIS-like [100918] (4 proteins)
  12. a.4.1.13: SLIDE domain [100998] (1 protein)
    myb-related probable DNA-binding motif
    automatically mapped to Pfam PF09111
  13. a.4.1.14: Middle operon regulator, Mor [109659] (1 protein)
    contains extra N-terminal dimerisation subdomain: alpha-hairpin (27-72) dimer is a four-helical bundle with right-handed twist
    automatically mapped to Pfam PF08765
  14. a.4.1.15: Psq domain [140213] (1 protein)
    Pfam PF05225
  15. a.4.1.16: Alr1493-like [140216] (1 protein)
    Pfam PF04255; DUF433; contains extra C-terminal helix and N-terminal dimerisation interlock subdomain (47405)
  16. a.4.1.17: Nanomeric phage protein-like [140219] (1 protein)
    contains additional N and C-terminal helices and the C-terminal beta-strand forming an intersubunit beta-barrel with a channel
    automatically mapped to Pfam PF13022
  17. a.4.1.18: SWIRM domain [140222] (4 proteins)
    Pfam PF04433; contains extra N-terminal helix
  18. a.4.1.19: Cgl2762-like [158260] (1 protein)
    Pfam PF01527; Transposase 8
  19. a.4.1.20: RpiR-like [158263] (1 protein)
    Pfam PF01418; contains two extra helices, one at each termini; overall arrangment of five helices is similar to the helical core of the lambda integrase-like catalytic domain (56350)
  20. a.4.1.0: automated matches [191447] (1 protein)
    not a true family
  21. a.4.1.21: DNA-binding domain of RAG1 [418810] (1 protein)
    N-terminal part of Pfam PF12940

More info for Superfamily a.4.1: Homeodomain-like

Timeline for Superfamily a.4.1: Homeodomain-like: