Lineage for Fold a.4: DNA/RNA-binding 3-helical bundle

  1. Root: SCOP 1.67
  2. 349259Class a: All alpha proteins [46456] (202 folds)
  3. 351236Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (12 superfamilies)
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

Superfamilies:

  1. 351237a.4.1: Homeodomain-like [46689] (12 families) (S)
    consists only of helices
  2. 351591a.4.2: Methylated DNA-protein cysteine methyltransferase, C-terminal domain [46767] (1 family) (S)
  3. 351604a.4.3: ARID-like [46774] (1 family) (S)
    contains extra helices at both N- and C-termini
  4. 351617a.4.5: "Winged helix" DNA-binding domain [46785] (45 families) (S)
    contains a small beta-sheet (wing)
  5. 352180a.4.6: C-terminal effector domain of the bipartite response regulators [46894] (3 families) (S)
    binds to DNA and RNA polymerase; the N-terminal, receiver domain belongs to the CheY family
  6. 352241a.4.7: Ribosomal protein L11, C-terminal domain [46906] (1 family) (S)
  7. 352257a.4.8: Ribosomal protein S18 [46911] (1 family) (S)
  8. 352277a.4.9: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 [46915] (1 family) (S)
  9. 352283a.4.10: N-terminal Zn binding domain of HIV integrase [46919] (1 family) (S)
  10. 352306a.4.11: RNA polymerase subunit RPB10 [46924] (1 family) (S)
  11. 352316a.4.12: TrpR-like [48295] (2 families) (S)
    contains an extra shared helix after the HTH motif
  12. 352353a.4.13: Sigma3 and sigma4 domains of RNA polymerase sigma factors [88659] (2 families) (S)

More info for Fold a.4: DNA/RNA-binding 3-helical bundle

Timeline for Fold a.4: DNA/RNA-binding 3-helical bundle: