SCOPe 2.05: Fold a.2: Long alpha-hairpin

Lineage for Fold a.2: Long alpha-hairpin

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.2: Long alpha-hairpin [46556] (20 superfamilies)
   2 helices; antiparallel hairpin, left-handed twist

Superfamilies:

1. a.2.1: GreA transcript cleavage protein, N-terminal domain [46557] (2 families)
   automatically mapped to Pfam PF03449

2. a.2.2: Ribosomal protein L29 (L29p) [46561] (1 family)
   automatically mapped to Pfam PF00831

3. a.2.3: Chaperone J-domain [46565] (2 families)

4. a.2.5: Prefoldin [46579] (1 family)

5. a.2.6: HR1 repeat [46585] (1 family)

6. a.2.7: tRNA-binding arm [46589] (5 families)
   formerly a class II aminoacyl-tRNA synthetase N-domain

7. a.2.8: Eukaryotic DNA topoisomerase I, dispensable insert domain [46596] (1 family)

8. a.2.9: C-terminal UvrC-binding domain of UvrB [46600] (1 family)

9. a.2.10: Epsilon subunit of F1F0-ATP synthase C-terminal domain [46604] (2 families)

10. a.2.11: Fe,Mn superoxide dismutase (SOD), N-terminal domain [46609] (2 families)
    automatically mapped to Pfam PF00081

11. a.2.12: Sporulation inhibitor Sda [100985] (1 family)
    automatically mapped to Pfam PF08970

12. a.2.13: Transcriptional repressor TraM [109631] (1 family)
    similar structure to L29p (46561); contains extra short helix; forms homodimer: an open bundle
    automatically mapped to Pfam PF09228

13. a.2.14: DnaK suppressor protein DksA, alpha-hairpin domain [109635] (1 family)

14. a.2.15: ISY1 domain-like [140102] (1 family)
    automatically mapped to Pfam PF06246

15. a.2.16: Calcyclin-binding protein-like [140106] (1 family)

16. a.2.17: Endosomal sorting complex assembly domain [140111] (3 families)
    forms 'fan'-like heterooligomers, in which the domains of different subunit make similar interactions at the tip of the hairpin

17. a.2.18: SPy1572-like [140121] (1 family)
    forms homodimer: an open bundle, different from the TRAM dimer
    automatically mapped to Pfam PF08930

18. a.2.19: Rabenosyn-5 Rab-binding domain-like [140125] (1 family)

19. a.2.20: MxiH-like [140129] (2 families)
    Type III secretion system needle

20. a.2.21: YnzC-like [158221] (1 family)

More info for Fold a.2: Long alpha-hairpin

Timeline for Fold a.2: Long alpha-hairpin:

• Fold a.2: Long alpha-hairpin first appeared (with stable ids) in SCOP 1.55
  
• Fold a.2: Long alpha-hairpin appears in SCOPe 2.04
  
• Fold a.2: Long alpha-hairpin appears in SCOPe 2.06
  
• Fold a.2: Long alpha-hairpin appears in the current release, SCOPe 2.08