SCOP 1.75: Family a.1.1.2: Globins

Lineage for Family a.1.1.2: Globins

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.1: Globin-like [46457] (2 superfamilies)
   core: 6 helices; folded leaf, partly opened

4. Superfamily a.1.1: Globin-like [46458] (4 families)

5. Family a.1.1.2: Globins [46463] (26 proteins)
   Heme-binding protein

Proteins:

1. Ascaris hemoglobin, domain 1 [46520] (1 species)

   • Species Pig roundworm (Ascaris suum) [TaxId:6253] [46521] (1 PDB entry)

2. Bacterial dimeric hemoglobin [46526] (1 species)

   • Species Vitreoscilla stercoraria [TaxId:61] [46527] (4 PDB entries)

3. Chimeric hemoglobin beta-alpha [46516] (1 species)

   • Species Synthetic, based on Homo sapiens sequence [46517] (1 PDB entry)

4. Cytoglobin [109626] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [109627] (6 PDB entries)
     Uniprot Q8WWM9 18-171

5. Dehaloperoxidase [46530] (1 species)

   • Species Amphitrite ornata [TaxId:129555] [46531] (3 PDB entries)

6. Erythrocruorin [46479] (1 species)

   • Species Midge (Chironomus thummi thummi), fraction III [TaxId:7154] [46480] (4 PDB entries)

7. Extracellular dodecameric hemoglobin (erythrocruorin), subunit D1 [116758] (1 species)

   • Species Common earthworm (Lumbricus terrestris) [TaxId:6398] [116759] (2 PDB entries)
     Uniprot O61233 19-158

8. Extracellular dodecameric hemoglobin (erythrocruorin), subunit II (globin B) [116754] (1 species)

   • Species Common earthworm (Lumbricus terrestris) [TaxId:6398] [116755] (2 PDB entries)
     Uniprot P02218

9. Extracellular dodecameric hemoglobin (erythrocruorin), subunit III (globin C) [116756] (1 species)

   • Species Common earthworm (Lumbricus terrestris) [TaxId:6398] [116757] (2 PDB entries)
     Uniprot P11069 20-168

10. Extracellular dodecameric hemoglobin (erythrocruorin), subunit IV (globin A) [116752] (1 species)

    • Species Common earthworm (Lumbricus terrestris) [TaxId:6398] [116753] (2 PDB entries)
      Uniprot P13579

11. Flavohemoglobin, N-terminal domain [46528] (2 species)

    1. Species Alcaligenes eutrophus [TaxId:106590] [46529] (1 PDB entry)

    2. Species Escherichia coli [TaxId:562] [74663] (1 PDB entry)

12. Glycera globin [46467] (1 species)

    • Species Marine bloodworm (Glycera dibranchiata) [TaxId:6350] [46468] (8 PDB entries)

13. Hagfish hemoglobin [68941] (1 species)

    • Species Inshore hagfish (Eptatretus burgeri) [TaxId:7764] [68942] (2 PDB entries)

14. Heme-based aerotactic transducer HemAT, sensor domain [100980] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [100981] (2 PDB entries)

15. Hemoglobin [46522] (1 species)

    • Species Innkeeper worm (Urechis caupo) [TaxId:6431] [46523] (1 PDB entry)

16. Hemoglobin I [46464] (2 species)

    1. Species Ark clam (Scapharca inaequivalvis) [TaxId:6561] [46465] (17 PDB entries)

    2. Species Clam (Lucina pectinata) [TaxId:244486] [46466] (4 PDB entries)

17. Hemoglobin, alpha-chain [46486] (20 species)

    1. Species Aldabra giant tortoise (Geochelone gigantea) [TaxId:167804] [100976] (3 PDB entries)
       Uniprot P83134

    2. Species Antarctic fish (Trematomus newnesi) [TaxId:35730] [46497] (4 PDB entries)

    3. Species Bar-headed goose (Anser indicus) [TaxId:8846] [46493] (3 PDB entries)

    4. Species Bluefin tuna (Thunnus thynnus) [TaxId:8237] [109623] (3 PDB entries)
       Uniprot Q8AYM0

    5. Species Cartilaginous fish akaei (Dasyatis akajei) [TaxId:31902] [46496] (2 PDB entries)

    6. Species Chicken (Gallus gallus) [TaxId:9031] [46492] (1 PDB entry)

    7. Species Cow (Bos taurus) [TaxId:9913] [46490] (8 PDB entries)

    8. Species Deer (Odocoileus virginianus) [TaxId:9874] [46489] (1 PDB entry)

    9. Species Donkey (Equus asinus) [TaxId:9793] [158217] (1 PDB entry)
       Uniprot P01959 1-141
       beta-chain sequences of donkey and horse hemoglobins are identical

    10. Species Emerald rockcod (Pagothenia bernacchii) [TaxId:40690] [46495] (7 PDB entries)

    11. Species Fish (Leiostomus xanthurus) [TaxId:59837] [46498] (1 PDB entry)

    12. Species Graylag goose (Anser anser) [TaxId:8843] [68938] (1 PDB entry)

    13. Species Horse (Equus caballus) [TaxId:9796] [46488] (14 PDB entries)

    14. Species Houndshark (Mustelus griseus) [TaxId:89020] [46499] (2 PDB entries)

    15. Species Human (Homo sapiens) [TaxId:9606] [46487] (178 PDB entries)
        Uniprot P69905 P01922 P01934 P01935

    16. Species Human (Homo sapiens), zeta isoform [TaxId:9606] [68937] (1 PDB entry)

    17. Species Maned wolf (Chrysocyon brachyurus) [TaxId:68728] [63440] (2 PDB entries)

    18. Species Pig (Sus scrofa) [TaxId:9823] [46491] (2 PDB entries)

    19. Species Trout (Oncorhynchus mykiss) [TaxId:8022] [46494] (2 PDB entries)

    20. Species Yellow perch (Perca flavescens) [TaxId:8167] [116749] (1 PDB entry)
        Uniprot P83270; 78% sequence identity

18. Hemoglobin, beta-chain [46500] (24 species)

    1. Species Aldabra giant tortoise (Geochelone gigantea) [TaxId:167804] [100977] (3 PDB entries)
       Uniprot P83133

    2. Species Antarctic fish (Trematomus newnesi) [TaxId:35730] [46513] (4 PDB entries)

    3. Species Bar-headed goose (Anser indicus) [TaxId:8846] [46509] (3 PDB entries)

    4. Species Bluefin tuna (Thunnus thynnus) [TaxId:8237] [109624] (3 PDB entries)
       Uniprot Q8AYM1

    5. Species Canis lupus familiaris [TaxId:9615] [158218] (1 PDB entry)

    6. Species Cartilaginous fish akaei (Dasyatis akajei) [TaxId:31902] [46512] (2 PDB entries)

    7. Species Chicken (Gallus gallus) [TaxId:9031] [46508] (1 PDB entry)

    8. Species Cow (Bos taurus) [TaxId:9913] [46506] (8 PDB entries)

    9. Species Deer (Odocoileus virginianus) [TaxId:9874] [46505] (1 PDB entry)

    10. Species Donkey (Equus asinus) [TaxId:9793] [158216] (1 PDB entry)
        beta-chain sequences of donkey and horse hemoglobins are identical

    11. Species Emerald rockcod (Pagothenia bernacchii) [TaxId:40690] [46511] (7 PDB entries)

    12. Species Fish (Leiostomus xanthurus) [TaxId:59837] [46514] (1 PDB entry)

    13. Species Graylag goose (Anser anser) [TaxId:8843] [68940] (1 PDB entry)

    14. Species Horse (Equus caballus) [TaxId:9796] [46504] (14 PDB entries)

    15. Species Houndshark (Mustelus griseus) [TaxId:89020] [46515] (2 PDB entries)

    16. Species Human (Homo sapiens) [TaxId:9606] [46501] (177 PDB entries)
        Uniprot P68871

    17. Species Human (Homo sapiens), delta-chain [TaxId:9606] [116750] (2 PDB entries)
        Uniprot P02042

    18. Species Human (Homo sapiens), embryonic gower II [TaxId:9606] [46503] (1 PDB entry)

    19. Species Human fetus (Homo sapiens), gamma-chain [TaxId:9606] [46502] (3 PDB entries)

    20. Species Maned wolf (Chrysocyon brachyurus) [TaxId:68728] [63441] (1 PDB entry)

    21. Species Mouse (Mus musculus) [TaxId:10090] [68939] (1 PDB entry)

    22. Species Pig (Sus scrofa) [TaxId:9823] [46507] (2 PDB entries)

    23. Species Trout (Oncorhynchus mykiss) [TaxId:8022] [46510] (2 PDB entries)

    24. Species Yellow perch (Perca flavescens) [TaxId:8167] [116751] (4 PDB entries)
        Uniprot P83273; 86% sequence identity

19. Hemoglobin, different isoforms [46524] (1 species)

    • Species Caudina arenicola, also known as Molpadia arenicola [TaxId:7698] [46525] (2 PDB entries)

20. Hypothetical protein PA3967 [109628] (1 species)

    • Species Pseudomonas aeruginosa [TaxId:287] [109629] (1 PDB entry)
      Uniprot Q9HX49

21. Lamprey globin [46518] (2 species)

    1. Species Lamprey (Lampetra fluviatilis) [TaxId:7748] [88966] (1 PDB entry)

    2. Species Sea lamprey (Petromyzon marinus) [TaxId:7757] [46519] (4 PDB entries)

22. Leghemoglobin [46481] (2 species)

    1. Species Soybean (Glycine max), isoform A [TaxId:3847] [46483] (2 PDB entries)

    2. Species Yellow lupin (Lupinus luteus) [TaxId:3873] [46482] (17 PDB entries)

23. Myoglobin [46469] (9 species)

    1. Species Asian elephant (Elephas maximus) [TaxId:9783] [46476] (1 PDB entry)

    2. Species Common seal (Phoca vitulina) [TaxId:9720] [46472] (1 PDB entry)

    3. Species Horse (Equus caballus) [TaxId:9796] [46474] (45 PDB entries)

    4. Species Human (Homo sapiens) [TaxId:9606] [46475] (1 PDB entry)

    5. Species Loggerhead sea turtle (Caretta caretta) [TaxId:8467] [46477] (2 PDB entries)

    6. Species Pig (Sus scrofa) [TaxId:9823] [46473] (17 PDB entries)

    7. Species Slug sea hare (Aplysia limacina) [TaxId:6502] [46471] (7 PDB entries)

    8. Species Sperm whale (Physeter catodon) [TaxId:9755] [46470] (180 PDB entries)
       Uniprot P02185

    9. Species Yellowfin tuna (Thunnus albacares) [TaxId:8236] [46478] (1 PDB entry)

24. Neuroglobin [100978] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [100979] (1 PDB entry)

    2. Species Mouse (Mus musculus) [TaxId:10090] [109625] (3 PDB entries)
       Uniprot Q9ER97

25. Non-symbiotic plant hemoglobin [46484] (1 species)

    • Species Rice (Oryza sativa) [TaxId:4530] [46485] (1 PDB entry)

26. Trematode hemoglobin/myoglobin [63438] (1 species)

    • Species Paramphistomum epiclitum [TaxId:54403] [63439] (2 PDB entries)

More info for Family a.1.1.2: Globins

Timeline for Family a.1.1.2: Globins:

• Family a.1.1.2: Globins first appeared (with stable ids) in SCOP 1.55
  
• Family a.1.1.2: Globins appears in SCOP 1.73
  
• Family a.1.1.2: Globins appears in SCOPe 2.01
  
• Family a.1.1.2: Globins appears in the current release, SCOPe 2.08