SCOPe 2.01: Domain d1wwww_: 1www W:

Lineage for d1wwww_ (1www W:)

1. Root: SCOPe 2.01

2. Class g: Small proteins [56992] (90 folds)

3. Fold g.17: Cystine-knot cytokines [57500] (1 superfamily)
   disulfide-rich fold; common core is all-beta

4. Superfamily g.17.1: Cystine-knot cytokines [57501] (8 families)

5. Family g.17.1.3: Neurotrophin [57520] (5 proteins)

6. Protein beta-Nerve growth factor [57525] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [57527] (3 PDB entries)
   Uniprot P01138

8. Domain d1wwww_: 1www W: [44808]
   Other proteins in same PDB: d1wwwx_, d1wwwy_

Details for d1wwww_

PDB Entry: 1www, 2.2 Å

PDB Description: ngf in complex with domain 5 of the trka receptor

PDB Compounds: (W:) protein (nerve growth factor)

SCOPe Domain Sequences for d1wwww_:

Sequence, based on SEQRES records:

>d1wwww_ g.17.1.3 (W:) beta-Nerve growth factor {Human (Homo sapiens) [TaxId: 9606]}
sshpifhrgefsvcdsvsvwvgdkttatdikgkevmvlgevninnsvfkqyffetkcrdp
npvdsgcrgidskhwnsycttthtfvkaltmdgkqaawrfiridtacvcvlsrka

Sequence, based on observed residues (ATOM records):

>d1wwww_ g.17.1.3 (W:) beta-Nerve growth factor {Human (Homo sapiens) [TaxId: 9606]}
sshpifhrgefsvcdsvsvwvgdkttatdikgkevmvlgevninnsvfkqyffetkcrdg
crgidskhwnsycttthtfvkaltmdgkqaawrfiridtacvcvlsrka

Timeline for d1wwww_:

• d1wwww_ first appeared (with stable ids) in SCOP 1.55
  
• d1wwww_ appears in SCOP 1.75
  
• d1wwww_ appears in SCOPe 2.02
  
• d1wwww_ appears in the current release, SCOPe 2.08