SCOP 1.75: Domain d1a35a2: 1a35 A:215-430

Lineage for d1a35a2 (1a35 A:215-430)

1. Root: SCOP 1.75

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.15: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1 superfamily)
   2 domains: alpha+beta and all-beta

4. Superfamily e.15.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56741] (1 family)

5. Family e.15.1.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56742] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56743] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56744] (15 PDB entries)
   Uniprot P11387 203-765
   Uniprot P11387 203-767
   Uniprot P11387 203-765 ! Uniprot P11387 203-767

8. Domain d1a35a2: 1a35 A:215-430 [43264]
   Other proteins in same PDB: d1a35a1
   protein/DNA complex; complexed with bru; mutant

Details for d1a35a2

PDB Entry: 1a35, 2.5 Å

PDB Description: human topoisomerase i/dna complex

PDB Compounds: (A:) protein (DNA topoisomerase I)

SCOP Domain Sequences for d1a35a2:

Sequence; same for both SEQRES and ATOM records:

>d1a35a2 e.15.1.1 (A:215-430) Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment {Human (Homo sapiens) [TaxId: 9606]}
ikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatffakmldheyttkeif
rknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqmskeeklkikeenekl
lkeygfcimdnhkerianfkieppglfrgrgnhpkmgmlkrrimpediiincskdakvps
pppghkwkevrhdnkvtwlvswteniqgsikyimln

Timeline for d1a35a2:

• d1a35a2 first appeared (with stable ids) in SCOP 1.55
  
• d1a35a2 appears in SCOP 1.73
  
• d1a35a2 appears in SCOPe 2.01
  
• d1a35a2 appears in the current release, SCOPe 2.08