SCOPe 2.04: Domain d2hmib_: 2hmi B:

Lineage for d2hmib_ (2hmi B:)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (3 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (145 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d2hmib_: 2hmi B: [43107]
   Other proteins in same PDB: d2hmia1, d2hmic1, d2hmic2, d2hmid1, d2hmid2
   protein/DNA complex

Details for d2hmib_

PDB Entry: 2hmi, 2.8 Å

PDB Description: hiv-1 reverse transcriptase/fragment of fab 28/dna complex

PDB Compounds: (B:) hisubunit of v-1 reverse transcriptase

SCOPe Domain Sequences for d2hmib_:

Sequence; same for both SEQRES and ATOM records:

>d2hmib_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqle

Timeline for d2hmib_:

• d2hmib_ first appeared (with stable ids) in SCOP 1.55, called d2hmib1
  
• d2hmib_ appears in SCOPe 2.03
  
• d2hmib_ appears in SCOPe 2.05
  
• d2hmib_ appears in the current release, SCOPe 2.08