SCOPe 2.06: Domain d1c1cb_: 1c1c B:

Lineage for d1c1cb_ (1c1c B:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (4 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (172 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d1c1cb_: 1c1c B: [43087]
   Other proteins in same PDB: d1c1ca1
   complexed with 612

Details for d1c1cb_

PDB Entry: 1c1c, 2.5 Å

PDB Description: crystal structure of hiv-1 reverse transcriptase in complex with tnk-6123

PDB Compounds: (B:) hiv-1 reverse transcriptase (b-chain)

SCOPe Domain Sequences for d1c1cb_:

Sequence, based on SEQRES records:

>d1c1cb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedf
rkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqym
ddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpi
vlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelela
enreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtnd
vkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvk
lwyqlekepivgaetf

Sequence, based on observed residues (ATOM records):

>d1c1cb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwgiphpaglkkkksvtvldvgdayfsvpldedfrkyt
aftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddly
vgsdleigqhrtkieelrqhllrwgltyelhpdkwtvqpivlpekdswtvndiqklvgkl
nwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskd
liaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwg
ktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetf

Timeline for d1c1cb_:

• d1c1cb_ first appeared (with stable ids) in SCOP 1.55, called d1c1cb1
  
• d1c1cb_ appears in SCOPe 2.05
  
• d1c1cb_ appears in SCOPe 2.07
  
• d1c1cb_ appears in the current release, SCOPe 2.08