SCOPe 2.06: Domain d1fk9b_: 1fk9 B:

Lineage for d1fk9b_ (1fk9 B:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (4 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (172 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d1fk9b_: 1fk9 B: [43081]
   Other proteins in same PDB: d1fk9a1
   complexed with efz

Details for d1fk9b_

PDB Entry: 1fk9, 2.5 Å

PDB Description: crystal structure of hiv-1 reverse transcriptase in complex with dmp- 266(efavirenz)

PDB Compounds: (B:) hiv-1 rt, b-chain

SCOPe Domain Sequences for d1fk9b_:

Sequence, based on SEQRES records:

>d1fk9b_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymd
dlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyq

Sequence, based on observed residues (ATOM records):

>d1fk9b_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwiphpaglkkkksvtvldvgdayfsvpldedfrkytaf
tipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvg
sdleigqhrtkieelrqhllrwglttpdkkgyelhpdkwtvqpivlpekdswtvndiqkl
vgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyyd
pskdliaeiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwgk
tpkfklpiqketwetwwteywqatwipewefvntpplvklwyq

Timeline for d1fk9b_:

• d1fk9b_ first appeared (with stable ids) in SCOP 1.55, called d1fk9b1
  
• d1fk9b_ appears in SCOPe 2.05
  
• d1fk9b_ appears in SCOPe 2.07
  
• d1fk9b_ appears in the current release, SCOPe 2.08